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- W2281539095 abstract "With recent advances in cellular biology, we now appreciate that modifications to DNA and histones can have a profound impact on transcription and function, even in the absence of changes to DNA sequence. These modifications, now commonly referred to as “epigenetic” alterations, have changed how we understand cell behavior, reprogramming and differentiation and have provided significant insight into the mechanisms underlying carcinogenesis. Epigenetic alterations, to this point, are largely identified by changes in DNA methylation and hydroxymethylation as well as methylation, acetylation, and phosphorylation of histone tails. These modifications enable significant flexibility in gene expression, rather than just turning genes “ON” or “OFF.” Herein we describe the epigenetic landscape in the regulation of gene expression with a particular focus on interrogating DNA methylation in myeloid malignancy." @default.
- W2281539095 created "2016-06-24" @default.
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- W2281539095 creator A5038836803 @default.
- W2281539095 creator A5060452476 @default.
- W2281539095 creator A5090621600 @default.
- W2281539095 date "2016-07-01" @default.
- W2281539095 modified "2023-10-08" @default.
- W2281539095 title "Epigenetics: A primer for clinicians" @default.
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