Matches in SemOpenAlex for { <https://semopenalex.org/work/W2281564467> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2281564467 endingPage "F436" @default.
- W2281564467 startingPage "F430" @default.
- W2281564467 abstract "Para-aminohippurate (PAH) is secreted at different rates in S1, S2, and S3 segments of isolated perfused proximal tubules of rabbit kidney. To characterize PAH transport we determined the maximal rate of secretion (Vmax) and the apparent Michaelis constant (Km) for each segment by examining the relationship between bath concentration of PAH and net PAH secretion (Jb leads to lPAH) transposed for Lineweaver-Burk analysis. The passive component of secretion for all segments was estimated by slope analysis at relatively high concentrations of PAH, by the component of PAH secretion insensitive to inhibition by probenecid, and, additionally, in S2 segments, from PAH efflux from lumen to bath. Subtraction of the passive component from Jb leads to lPAH (probenecid method) gave Vmax values for S1, S2, and S3 segments of 1,097 +/- 336 (n = 6), 7,430 +/- 1,338 (n = 6), 1,647 +/+ 138 (n = 8) X 10(-15) mol.min-1.mm-1 (+/- SE) and apparent Km values of 139 +/– 37 (n = 6), 195 +/- 37 (n = 6), and 113 +/- 16 (n = 6) X 10(-6) M, respectively. Thus, Vmax for S2 greater than S3 congruent to S1, whereas apparent Km was not consistently different among the segments. On the basis of these results we suggest that axial heterogeneity of PAH secretion may reflect an increased basolateral membrane density of PAH transporters of common affinity in the S2 segment of the proximal tubule." @default.
- W2281564467 created "2016-06-24" @default.
- W2281564467 creator A5038158072 @default.
- W2281564467 creator A5073351772 @default.
- W2281564467 creator A5090456936 @default.
- W2281564467 date "1981-05-01" @default.
- W2281564467 modified "2023-09-26" @default.
- W2281564467 title "Basis for heterogeneity of para-aminohippurate secretion in rabbit proximal tubules" @default.
- W2281564467 doi "https://doi.org/10.1152/ajprenal.1981.240.5.f430" @default.
- W2281564467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7235017" @default.
- W2281564467 hasPublicationYear "1981" @default.
- W2281564467 type Work @default.
- W2281564467 sameAs 2281564467 @default.
- W2281564467 citedByCount "23" @default.
- W2281564467 countsByYear W22815644672016 @default.
- W2281564467 countsByYear W22815644672017 @default.
- W2281564467 countsByYear W22815644672019 @default.
- W2281564467 crossrefType "journal-article" @default.
- W2281564467 hasAuthorship W2281564467A5038158072 @default.
- W2281564467 hasAuthorship W2281564467A5073351772 @default.
- W2281564467 hasAuthorship W2281564467A5090456936 @default.
- W2281564467 hasConcept C104317684 @default.
- W2281564467 hasConcept C126322002 @default.
- W2281564467 hasConcept C131631996 @default.
- W2281564467 hasConcept C134018914 @default.
- W2281564467 hasConcept C149011108 @default.
- W2281564467 hasConcept C159641895 @default.
- W2281564467 hasConcept C181199279 @default.
- W2281564467 hasConcept C185592680 @default.
- W2281564467 hasConcept C2776769776 @default.
- W2281564467 hasConcept C2776982352 @default.
- W2281564467 hasConcept C2780091579 @default.
- W2281564467 hasConcept C2780222010 @default.
- W2281564467 hasConcept C28212737 @default.
- W2281564467 hasConcept C49039625 @default.
- W2281564467 hasConcept C55493867 @default.
- W2281564467 hasConcept C64915919 @default.
- W2281564467 hasConcept C71924100 @default.
- W2281564467 hasConcept C86803240 @default.
- W2281564467 hasConceptScore W2281564467C104317684 @default.
- W2281564467 hasConceptScore W2281564467C126322002 @default.
- W2281564467 hasConceptScore W2281564467C131631996 @default.
- W2281564467 hasConceptScore W2281564467C134018914 @default.
- W2281564467 hasConceptScore W2281564467C149011108 @default.
- W2281564467 hasConceptScore W2281564467C159641895 @default.
- W2281564467 hasConceptScore W2281564467C181199279 @default.
- W2281564467 hasConceptScore W2281564467C185592680 @default.
- W2281564467 hasConceptScore W2281564467C2776769776 @default.
- W2281564467 hasConceptScore W2281564467C2776982352 @default.
- W2281564467 hasConceptScore W2281564467C2780091579 @default.
- W2281564467 hasConceptScore W2281564467C2780222010 @default.
- W2281564467 hasConceptScore W2281564467C28212737 @default.
- W2281564467 hasConceptScore W2281564467C49039625 @default.
- W2281564467 hasConceptScore W2281564467C55493867 @default.
- W2281564467 hasConceptScore W2281564467C64915919 @default.
- W2281564467 hasConceptScore W2281564467C71924100 @default.
- W2281564467 hasConceptScore W2281564467C86803240 @default.
- W2281564467 hasIssue "5" @default.
- W2281564467 hasLocation W22815644671 @default.
- W2281564467 hasLocation W22815644672 @default.
- W2281564467 hasOpenAccess W2281564467 @default.
- W2281564467 hasPrimaryLocation W22815644671 @default.
- W2281564467 hasRelatedWork W1985730712 @default.
- W2281564467 hasRelatedWork W2020884724 @default.
- W2281564467 hasRelatedWork W2058039910 @default.
- W2281564467 hasRelatedWork W2127085070 @default.
- W2281564467 hasRelatedWork W2159390875 @default.
- W2281564467 hasRelatedWork W2161296685 @default.
- W2281564467 hasRelatedWork W2180940015 @default.
- W2281564467 hasRelatedWork W2281564467 @default.
- W2281564467 hasRelatedWork W2412346139 @default.
- W2281564467 hasRelatedWork W1950704265 @default.
- W2281564467 hasVolume "240" @default.
- W2281564467 isParatext "false" @default.
- W2281564467 isRetracted "false" @default.
- W2281564467 magId "2281564467" @default.
- W2281564467 workType "article" @default.