FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2281564613> ?p ?o ?g. }

• W2281564613 endingPage "435" @default.
• W2281564613 startingPage "425" @default.
• W2281564613 abstract "1. The fate of [14C]amphetamine in man, rhesus monkey, greyhound, rat, rabbit, mouse and guinea pig has been studied. 2. In three men receiving orally 5mg each (about 0.07mg/kg), about 90% of the 14C was excreted in the urine in 3–4 days. About 60–65% of the 14C was excreted in 1 day, 30% as unchanged drug, 21% as total benzoic acid and 3% as 4-hydroxyamphetamine. 3. In two rhesus monkeys (dose 0.66mg/kg), the metabolites excreted in 24h were similar to those in man except that there was little 4-hydroxyamphetamine. 4. In greyhounds receiving 5mg/kg intraperitoneally the metabolites were similar in amount to those in man. 5. Rabbits receiving 10mg/kg orally differed from all other species. They excreted little unchanged amphetamine (4% of dose) and 4-hydroxyamphetamine (6%). They excreted in 24h mainly benzoic acid (total 25%), an acid-labile precursor of 1-phenylpropan-2-one (benzyl methyl ketone) (22%) and conjugated 1-phenylpropan-2-ol (benzylmethylcarbinol) (7%). 6. Rats receiving 10mg/kg orally also differed from other species. The main metabolite (60% of dose) was conjugated 4-hydroxyamphetamine. Minor metabolites were amphetamine (13%), N-acetylamphetamine (2%), norephedrine (0.3%) and 4-hydroxynorephedrine (0.3%). 7. The guinea pig receiving 5mg/kg excreted only benzoic acid and its conjugates (62%) and amphetamine (22%). 8. The mouse receiving 10mg/kg excreted amphetamine (33%), 4-hydroxyamphetamine (14%) and benzoic acid and its conjugates (31%). 9. Experiments on the precursor of 1-phenylpropan-2-one occurring in rabbit urine suggest that it might be the enol sulphate of the ketone. A very small amount of the ketone (1–3%) was also found in human and greyhound urine after acid hydrolysis." @default.
• W2281564613 created "2016-06-24" @default.
• W2281564613 creator A5001800797 @default.
• W2281564613 creator A5036461217 @default.
• W2281564613 creator A5044453328 @default.
• W2281564613 date "1970-02-01" @default.
• W2281564613 modified "2023-10-15" @default.
• W2281564613 title "The metabolic fate of amphetamine in man and other species" @default.
• W2281564613 cites W103781794 @default.
• W2281564613 cites W166229085 @default.
• W2281564613 cites W177876135 @default.
• W2281564613 cites W1943270839 @default.
• W2281564613 cites W1976606909 @default.
• W2281564613 cites W1986816394 @default.
• W2281564613 cites W1995875303 @default.
• W2281564613 cites W2009104866 @default.
• W2281564613 cites W2022998136 @default.
• W2281564613 cites W2052503447 @default.
• W2281564613 cites W2053507030 @default.
• W2281564613 cites W2055630286 @default.
• W2281564613 cites W2058604897 @default.
• W2281564613 cites W2063220916 @default.
• W2281564613 cites W2064727043 @default.
• W2281564613 cites W2070992812 @default.
• W2281564613 cites W2078332297 @default.
• W2281564613 cites W2236066974 @default.
• W2281564613 cites W2238237894 @default.
• W2281564613 cites W2271816444 @default.
• W2281564613 cites W2339127765 @default.
• W2281564613 cites W2342959189 @default.
• W2281564613 cites W2346308709 @default.
• W2281564613 cites W2402717004 @default.
• W2281564613 cites W2407729015 @default.
• W2281564613 cites W2415399201 @default.
• W2281564613 cites W2421565839 @default.
• W2281564613 cites W33680250 @default.
• W2281564613 cites W98016377 @default.
• W2281564613 doi "https://doi.org/10.1042/bj1160425" @default.
• W2281564613 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1185381" @default.
• W2281564613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4985156" @default.
• W2281564613 hasPublicationYear "1970" @default.
• W2281564613 type Work @default.
• W2281564613 sameAs 2281564613 @default.
• W2281564613 citedByCount "238" @default.
• W2281564613 countsByYear W22815646132012 @default.
• W2281564613 countsByYear W22815646132013 @default.
• W2281564613 countsByYear W22815646132014 @default.
• W2281564613 countsByYear W22815646132015 @default.
• W2281564613 countsByYear W22815646132016 @default.
• W2281564613 countsByYear W22815646132017 @default.
• W2281564613 countsByYear W22815646132018 @default.
• W2281564613 countsByYear W22815646132019 @default.
• W2281564613 countsByYear W22815646132020 @default.
• W2281564613 countsByYear W22815646132021 @default.
• W2281564613 countsByYear W22815646132022 @default.
• W2281564613 countsByYear W22815646132023 @default.
• W2281564613 crossrefType "journal-article" @default.
• W2281564613 hasAuthorship W2281564613A5001800797 @default.
• W2281564613 hasAuthorship W2281564613A5036461217 @default.
• W2281564613 hasAuthorship W2281564613A5044453328 @default.
• W2281564613 hasBestOaLocation W22815646132 @default.
• W2281564613 hasConcept C134018914 @default.
• W2281564613 hasConcept C185592680 @default.
• W2281564613 hasConcept C2777193897 @default.
• W2281564613 hasConcept C2777477808 @default.
• W2281564613 hasConcept C2778815084 @default.
• W2281564613 hasConcept C2778844314 @default.
• W2281564613 hasConcept C2780026642 @default.
• W2281564613 hasConcept C513476851 @default.
• W2281564613 hasConcept C55493867 @default.
• W2281564613 hasConcept C62231903 @default.
• W2281564613 hasConcept C71924100 @default.
• W2281564613 hasConcept C98274493 @default.
• W2281564613 hasConceptScore W2281564613C134018914 @default.
• W2281564613 hasConceptScore W2281564613C185592680 @default.
• W2281564613 hasConceptScore W2281564613C2777193897 @default.
• W2281564613 hasConceptScore W2281564613C2777477808 @default.
• W2281564613 hasConceptScore W2281564613C2778815084 @default.
• W2281564613 hasConceptScore W2281564613C2778844314 @default.
• W2281564613 hasConceptScore W2281564613C2780026642 @default.
• W2281564613 hasConceptScore W2281564613C513476851 @default.
• W2281564613 hasConceptScore W2281564613C55493867 @default.
• W2281564613 hasConceptScore W2281564613C62231903 @default.
• W2281564613 hasConceptScore W2281564613C71924100 @default.
• W2281564613 hasConceptScore W2281564613C98274493 @default.
• W2281564613 hasIssue "3" @default.
• W2281564613 hasLocation W22815646131 @default.
• W2281564613 hasLocation W22815646132 @default.
• W2281564613 hasLocation W22815646133 @default.
• W2281564613 hasLocation W22815646134 @default.
• W2281564613 hasLocation W22815646135 @default.
• W2281564613 hasOpenAccess W2281564613 @default.
• W2281564613 hasPrimaryLocation W22815646131 @default.
• W2281564613 hasRelatedWork W1753739957 @default.
• W2281564613 hasRelatedWork W1964139766 @default.
• W2281564613 hasRelatedWork W1983366598 @default.
• W2281564613 hasRelatedWork W2011282322 @default.
• W2281564613 hasRelatedWork W2012113795 @default.

• next