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- W2281587948 abstract "Abstract We originally isolated gp140, the receptor of human C3 (the third component of complement) from Raji, a human B lymphoma cell line (1981). gp140 is the C3d receptor (1983, 1985a) and also the Epstein-Barr virus receptor (1985b). Activated EBV/C3dR regulates B lymphocyte proliferation (1985c). EBV interaction with EBV/C3dR is the first step of B lymphocyte transformation (1985b). Activated EBV/C3dR interacts through its intracytoplasmic domain, with the p53 oncoprotein (1989, 1992, 1995) or a p68 Cabp (1991, 1992, 1995). We identified the two first signaling pathways specifically triggered by activated EBV/C3dR. The first pathway, independent of CD19 and BCR activation, is characterized by: 1) activation of pp60src kinase to tyrosine phosphorylate nucleolin; 2) tyrosine phosphorylated nucleolin interacts with the SH2 domains of the p85 subunit of PI-3 kinase, activating this latter; 3) activated PI 3-kinase recrutes the AKT-GSK3 pathway (1999, 2001, 2003). The second pathway is characterized by: 1) Cbl phosphorylation; 2) interactions of phosphorylated Cbl with Crk-L, Syk and the p85 subunit of PI-3-kinase; 3) dissociation of phosphorylated Cbl from Vav (2006). This dissociation, opposed to the Cbl-Vav association triggered by CD19 or BCR, emphasizes the specificity of EBV/C3dR signaling pathways. We herein identified the functional relationship between these two pathways." @default.
- W2281587948 created "2016-06-24" @default.
- W2281587948 creator A5002404664 @default.
- W2281587948 date "2009-04-01" @default.
- W2281587948 modified "2023-09-27" @default.
- W2281587948 title "The C3d/Epstein-Barr virus receptor (gp140, CR2, CD21, EBV/C3dR) triggers distinct signaling pathways, independently of CD19 or BCR, in human B lymphocytes. (84.1)" @default.
- W2281587948 doi "https://doi.org/10.4049/jimmunol.182.supp.84.1" @default.
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