Matches in SemOpenAlex for { <https://semopenalex.org/work/W2281605661> ?p ?o ?g. }
- W2281605661 endingPage "78" @default.
- W2281605661 startingPage "53" @default.
- W2281605661 abstract "β-Catenin is involved both in cadherin-mediated intercellular adhesion and transcriptional coactivation downstream of the Wnt signaling pathway. Accumulation of β-catenin by inhibition or knockout of its negative regulator GSK3 is known to sustain pluripotency in conjunction with other factors. However, dual function of β-catenin and context-dependence of its activities make it difficult to dissect the mechanisms underlying this phenomenon. β-Catenin transactivation function, which is considered to be associated with Wnt signaling, proved to be largely dispensable for the self-renewal of naïve embryonic stem cells, but required for differentiation. Instead, β-catenin-mediated adhesion is beneficial for self-renewal, though presumably its main role is to stabilize LIF/STAT3 pathway rather than to maintain intercellular contacts per se. Yet recent report implicates E-cadherin-independent cytoplasm activity of β-catenin in pluripotency maintenance. This review focuses on the new data concerning adhesion- and transcription-related activities of β-catenin in control of self-renewal versus differentiation in pluripotent stem cells, as well as analyzing binding partners of β-catenin in embryonic stem cells, which include key pluripotency regulators." @default.
- W2281605661 created "2016-06-24" @default.
- W2281605661 creator A5027218942 @default.
- W2281605661 creator A5086583788 @default.
- W2281605661 date "2014-01-01" @default.
- W2281605661 modified "2023-09-27" @default.
- W2281605661 title "β-Catenin in Pluripotency" @default.
- W2281605661 cites W1533016134 @default.
- W2281605661 cites W1581784145 @default.
- W2281605661 cites W160554039 @default.
- W2281605661 cites W1608843970 @default.
- W2281605661 cites W167797417 @default.
- W2281605661 cites W1886443720 @default.
- W2281605661 cites W1904046622 @default.
- W2281605661 cites W1963944722 @default.
- W2281605661 cites W1966621898 @default.
- W2281605661 cites W1970295705 @default.
- W2281605661 cites W1973493635 @default.
- W2281605661 cites W1974012180 @default.
- W2281605661 cites W1974183373 @default.
- W2281605661 cites W1981049955 @default.
- W2281605661 cites W1982975198 @default.
- W2281605661 cites W1987966039 @default.
- W2281605661 cites W1990000762 @default.
- W2281605661 cites W1990577927 @default.
- W2281605661 cites W1991955987 @default.
- W2281605661 cites W1997054356 @default.
- W2281605661 cites W2001896691 @default.
- W2281605661 cites W2002511118 @default.
- W2281605661 cites W2006419043 @default.
- W2281605661 cites W2006472255 @default.
- W2281605661 cites W2006579769 @default.
- W2281605661 cites W2006604617 @default.
- W2281605661 cites W2006743934 @default.
- W2281605661 cites W2006847376 @default.
- W2281605661 cites W2007558178 @default.
- W2281605661 cites W2008508734 @default.
- W2281605661 cites W2010672807 @default.
- W2281605661 cites W2018744859 @default.
- W2281605661 cites W2018965952 @default.
- W2281605661 cites W2025102507 @default.
- W2281605661 cites W2026598920 @default.
- W2281605661 cites W2027477293 @default.
- W2281605661 cites W2033319844 @default.
- W2281605661 cites W2036832250 @default.
- W2281605661 cites W2038833190 @default.
- W2281605661 cites W2041472984 @default.
- W2281605661 cites W2043473476 @default.
- W2281605661 cites W2045595996 @default.
- W2281605661 cites W2052097134 @default.
- W2281605661 cites W2052372354 @default.
- W2281605661 cites W2053959232 @default.
- W2281605661 cites W2054845602 @default.
- W2281605661 cites W2055570171 @default.
- W2281605661 cites W2058421656 @default.
- W2281605661 cites W2058521801 @default.
- W2281605661 cites W2059030354 @default.
- W2281605661 cites W2059772934 @default.
- W2281605661 cites W2069096667 @default.
- W2281605661 cites W2070354412 @default.
- W2281605661 cites W2073921309 @default.
- W2281605661 cites W2076367967 @default.
- W2281605661 cites W2079244861 @default.
- W2281605661 cites W2082773762 @default.
- W2281605661 cites W2083935868 @default.
- W2281605661 cites W2084258581 @default.
- W2281605661 cites W2084622863 @default.
- W2281605661 cites W2084760868 @default.
- W2281605661 cites W2087500600 @default.
- W2281605661 cites W2088128367 @default.
- W2281605661 cites W2089426706 @default.
- W2281605661 cites W2092125592 @default.
- W2281605661 cites W2094484000 @default.
- W2281605661 cites W2094831008 @default.
- W2281605661 cites W2096171021 @default.
- W2281605661 cites W2097946485 @default.
- W2281605661 cites W2101797075 @default.
- W2281605661 cites W2105878014 @default.
- W2281605661 cites W2114434551 @default.
- W2281605661 cites W2115860289 @default.
- W2281605661 cites W2116315632 @default.
- W2281605661 cites W2118447522 @default.
- W2281605661 cites W2120042091 @default.
- W2281605661 cites W2123604507 @default.
- W2281605661 cites W2123877065 @default.
- W2281605661 cites W2123911142 @default.
- W2281605661 cites W2124174391 @default.
- W2281605661 cites W2125418297 @default.
- W2281605661 cites W2125500637 @default.
- W2281605661 cites W2125933653 @default.
- W2281605661 cites W2126622935 @default.
- W2281605661 cites W2129201068 @default.
- W2281605661 cites W2130100751 @default.
- W2281605661 cites W2132085004 @default.
- W2281605661 cites W2133656012 @default.
- W2281605661 cites W2135279930 @default.
- W2281605661 cites W2136623538 @default.
- W2281605661 cites W2136995156 @default.