Matches in SemOpenAlex for { <https://semopenalex.org/work/W2281720105> ?p ?o ?g. }
- W2281720105 endingPage "9187" @default.
- W2281720105 startingPage "9175" @default.
- W2281720105 abstract "Cushing's disease is caused by pituitary corticotroph adenoma, and the pathogenesis of it has remained obscure. Here, we showed that cold inducible RNA binding protein (CIRP) was markedly elevated in corticotroph tumors. Forced overexpression of CIRP in murine AtT20 pituitary corticotroph cell line increased corticotroph precursor hormone proopiomelanocortin (POMC) transcription, ACTH secretion and cellular proliferation. In vivo, CIRP overexpression promotes murine corticotroph tumor growth and enhances ACTH production. Mechanistically, we show that CIRP could promote AtT20 cells proliferation by inducing cyclinD1 and decreasing p27 expression via Erk1/2 signaling pathway. Clinically, CIRP overexpression is significantly correlated with Cushing's disease recurrence. CIRP appears to play a critical tumorigenesis function in Cushing's disease and its expression might be a useful biomarker for tumor recurrence." @default.
- W2281720105 created "2016-06-24" @default.
- W2281720105 creator A5008868127 @default.
- W2281720105 creator A5010391473 @default.
- W2281720105 creator A5014719345 @default.
- W2281720105 creator A5034127226 @default.
- W2281720105 creator A5034654778 @default.
- W2281720105 creator A5041577172 @default.
- W2281720105 creator A5056161245 @default.
- W2281720105 creator A5066033944 @default.
- W2281720105 creator A5069611208 @default.
- W2281720105 creator A5083642725 @default.
- W2281720105 creator A5083727290 @default.
- W2281720105 creator A5088251627 @default.
- W2281720105 date "2016-01-27" @default.
- W2281720105 modified "2023-10-12" @default.
- W2281720105 title "Cold inducible RNA binding protein upregulation in pituitary corticotroph adenoma induces corticotroph cell proliferation via Erk signaling pathway" @default.
- W2281720105 cites W1910274646 @default.
- W2281720105 cites W1975953955 @default.
- W2281720105 cites W1979328434 @default.
- W2281720105 cites W1985008806 @default.
- W2281720105 cites W1989043763 @default.
- W2281720105 cites W1990995386 @default.
- W2281720105 cites W1995128552 @default.
- W2281720105 cites W1995462963 @default.
- W2281720105 cites W2002433286 @default.
- W2281720105 cites W2003523327 @default.
- W2281720105 cites W2013196047 @default.
- W2281720105 cites W2027091725 @default.
- W2281720105 cites W2028905350 @default.
- W2281720105 cites W2033505874 @default.
- W2281720105 cites W2053304669 @default.
- W2281720105 cites W2062289724 @default.
- W2281720105 cites W2086818383 @default.
- W2281720105 cites W2093010614 @default.
- W2281720105 cites W2094859123 @default.
- W2281720105 cites W2096048497 @default.
- W2281720105 cites W2105695548 @default.
- W2281720105 cites W2116711648 @default.
- W2281720105 cites W2118954256 @default.
- W2281720105 cites W2122569219 @default.
- W2281720105 cites W2127150495 @default.
- W2281720105 cites W2135938911 @default.
- W2281720105 cites W2147573461 @default.
- W2281720105 cites W2157881421 @default.
- W2281720105 cites W2160975452 @default.
- W2281720105 cites W2164388363 @default.
- W2281720105 cites W2168404575 @default.
- W2281720105 cites W41553625 @default.
- W2281720105 cites W4211186562 @default.
- W2281720105 doi "https://doi.org/10.18632/oncotarget.7037" @default.
- W2281720105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4891034" @default.
- W2281720105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26824322" @default.
- W2281720105 hasPublicationYear "2016" @default.
- W2281720105 type Work @default.
- W2281720105 sameAs 2281720105 @default.
- W2281720105 citedByCount "21" @default.
- W2281720105 countsByYear W22817201052016 @default.
- W2281720105 countsByYear W22817201052017 @default.
- W2281720105 countsByYear W22817201052018 @default.
- W2281720105 countsByYear W22817201052019 @default.
- W2281720105 countsByYear W22817201052020 @default.
- W2281720105 countsByYear W22817201052021 @default.
- W2281720105 countsByYear W22817201052022 @default.
- W2281720105 crossrefType "journal-article" @default.
- W2281720105 hasAuthorship W2281720105A5008868127 @default.
- W2281720105 hasAuthorship W2281720105A5010391473 @default.
- W2281720105 hasAuthorship W2281720105A5014719345 @default.
- W2281720105 hasAuthorship W2281720105A5034127226 @default.
- W2281720105 hasAuthorship W2281720105A5034654778 @default.
- W2281720105 hasAuthorship W2281720105A5041577172 @default.
- W2281720105 hasAuthorship W2281720105A5056161245 @default.
- W2281720105 hasAuthorship W2281720105A5066033944 @default.
- W2281720105 hasAuthorship W2281720105A5069611208 @default.
- W2281720105 hasAuthorship W2281720105A5083642725 @default.
- W2281720105 hasAuthorship W2281720105A5083727290 @default.
- W2281720105 hasAuthorship W2281720105A5088251627 @default.
- W2281720105 hasBestOaLocation W22817201051 @default.
- W2281720105 hasConcept C104317684 @default.
- W2281720105 hasConcept C121608353 @default.
- W2281720105 hasConcept C126322002 @default.
- W2281720105 hasConcept C127561419 @default.
- W2281720105 hasConcept C134018914 @default.
- W2281720105 hasConcept C170493617 @default.
- W2281720105 hasConcept C2776810848 @default.
- W2281720105 hasConcept C2777428134 @default.
- W2281720105 hasConcept C2779029589 @default.
- W2281720105 hasConcept C2779134260 @default.
- W2281720105 hasConcept C2779318953 @default.
- W2281720105 hasConcept C2781309135 @default.
- W2281720105 hasConcept C502942594 @default.
- W2281720105 hasConcept C54355233 @default.
- W2281720105 hasConcept C555283112 @default.
- W2281720105 hasConcept C57074206 @default.
- W2281720105 hasConcept C62112901 @default.
- W2281720105 hasConcept C62478195 @default.
- W2281720105 hasConcept C71315377 @default.
- W2281720105 hasConcept C71924100 @default.