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• W2281811821 abstract "Drugs of abuse are a group of chemical entities that are positively reinforcing and can shape behavior from recreational use towards abuse. As escalation of drug intake develops, users lose control over their decision-making processes and behavior is geared more towards obtaining and consuming drugs. Drugs of abuse trigger these behavioral alterations through long-lasting neuroadaptations in brain circuits that drive motivational learning and decision-making processes. Some of these brain alterations are driven by the actions of the mechanistic target of rapamycin (mTOR), which is activated by drugs of abuse and facilitates long-lasting protein synthesis-dependent changes in synaptic function. In this chapter, we detail the role that mTOR plays in the actions of each class of abused drugs, and how blocking the actions of mTOR reduces the development of harmful behaviors associated with escalated drug-seeking and -taking." @default.
• W2281811821 created "2016-06-24" @default.
• W2281811821 creator A5008613169 @default.
• W2281811821 creator A5080539480 @default.
• W2281811821 date "2016-01-01" @default.
• W2281811821 modified "2023-10-16" @default.
• W2281811821 title "mTOR and Drugs of Abuse" @default.
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• W2281811821 doi "https://doi.org/10.1016/b978-0-12-802733-2.00005-0" @default.
• W2281811821 hasPublicationYear "2016" @default.
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