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- W2281813928 abstract "Hypoxia-inducible factor (HIF)-1α regulates the expression of genes involved in angiogenesis, cellular energy metabolism, and cell survival during cancer development. The increased expression of HIF-1α in most solid tumors is associated with poor prognoses and therapeutic outcomes. Therefore, HIF has been recognized as an attractive target for cancer therapy, and many HIF inhibitors have been reported.This patent survey summarizes the information about patented HIF inhibitors over the last 5 years (2011-2015).Although many of the HIF inhibitors reviewed in this patent survey possess inhibitory activity against cancer and HIF-related diseases, the compounds are still in the early stages of development, most likely due to the complexity of the HIF-1 pathway and their different mechanisms of action for HIF inhibition. Most cancer cells use the glycolytic pathway for energy production and HIF-1α participates deeply in the expression of several glycolytic enzymes. Therefore, a detailed study of HIF's function in cancer metabolisms may provide us an alternative strategy for further development of HIF inhibitors in cancer therapy." @default.
- W2281813928 created "2016-06-24" @default.
- W2281813928 creator A5025266325 @default.
- W2281813928 creator A5026175736 @default.
- W2281813928 creator A5029428931 @default.
- W2281813928 creator A5071405443 @default.
- W2281813928 date "2016-02-16" @default.
- W2281813928 modified "2023-10-16" @default.
- W2281813928 title "Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015)" @default.
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- W2281813928 doi "https://doi.org/10.1517/13543776.2016.1146252" @default.
- W2281813928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26882240" @default.
- W2281813928 hasPublicationYear "2016" @default.
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