Matches in SemOpenAlex for { <https://semopenalex.org/work/W2281858917> ?p ?o ?g. }
- W2281858917 endingPage "e0149775" @default.
- W2281858917 startingPage "e0149775" @default.
- W2281858917 abstract "Objectives Hematoma quality (especially the fibrin matrix) plays an important role in the bone healing process. Here, we investigated the effect of interleukin-1 beta (IL-1β) on fibrin clot formation from platelet-poor plasma (PPP). Methods Five-milliliter of rat whole-blood samples were collected from the hepatic portal vein. All blood samples were firstly standardized via a thrombelastograph (TEG), blood cell count, and the measurement of fibrinogen concentration. PPP was prepared by collecting the top two-fifths of the plasma after centrifugation under 400 × g for 10 min at 20°C. The effects of IL-1β cytokines on artificial fibrin clot formation from PPP solutions were determined by scanning electronic microscopy (SEM), confocal microscopy (CM), turbidity, and clot lysis assays. Results The lag time for protofibril formation was markedly shortened in the IL-1β treatment groups (243.8 ± 76.85 in the 50 pg/mL of IL-1β and 97.5 ± 19.36 in the 500 pg/mL of IL-1β) compared to the control group without IL-1β (543.8 ± 205.8). Maximal turbidity was observed in the control group. IL-1β (500 pg/mL) treatment significantly decreased fiber diameters resulting in smaller pore sizes and increased density of the fibrin clot structure formed from PPP (P < 0.05). The clot lysis assay revealed that 500 pg/mL IL-1β induced a lower susceptibility to dissolution due to the formation of thinner and denser fibers. Conclusion IL-1β can significantly influence PPP fibrin clot structure, which may affect the early bone healing process." @default.
- W2281858917 created "2016-06-24" @default.
- W2281858917 creator A5006427323 @default.
- W2281858917 creator A5006822602 @default.
- W2281858917 creator A5026186846 @default.
- W2281858917 creator A5051762810 @default.
- W2281858917 creator A5067364038 @default.
- W2281858917 date "2016-02-24" @default.
- W2281858917 modified "2023-10-03" @default.
- W2281858917 title "Influence of Interleukin-1 Beta on Platelet-Poor Plasma Clot Formation: A Potential Impact on Early Bone Healing" @default.
- W2281858917 cites W1570078154 @default.
- W2281858917 cites W1913384604 @default.
- W2281858917 cites W1966068789 @default.
- W2281858917 cites W1979883641 @default.
- W2281858917 cites W1980051005 @default.
- W2281858917 cites W1983760732 @default.
- W2281858917 cites W1986447969 @default.
- W2281858917 cites W1986601137 @default.
- W2281858917 cites W1989075316 @default.
- W2281858917 cites W1990341278 @default.
- W2281858917 cites W1995302180 @default.
- W2281858917 cites W1998485366 @default.
- W2281858917 cites W2002096405 @default.
- W2281858917 cites W2007871863 @default.
- W2281858917 cites W2012985069 @default.
- W2281858917 cites W2013257757 @default.
- W2281858917 cites W2014679360 @default.
- W2281858917 cites W2015547514 @default.
- W2281858917 cites W2016139654 @default.
- W2281858917 cites W2016578709 @default.
- W2281858917 cites W2017466351 @default.
- W2281858917 cites W2024133931 @default.
- W2281858917 cites W2050454842 @default.
- W2281858917 cites W2057007282 @default.
- W2281858917 cites W2059628966 @default.
- W2281858917 cites W2059888954 @default.
- W2281858917 cites W2064369146 @default.
- W2281858917 cites W2068217394 @default.
- W2281858917 cites W2072100512 @default.
- W2281858917 cites W2074226229 @default.
- W2281858917 cites W2083601800 @default.
- W2281858917 cites W2083814433 @default.
- W2281858917 cites W2086897034 @default.
- W2281858917 cites W2091263418 @default.
- W2281858917 cites W2092707717 @default.
- W2281858917 cites W2105353628 @default.
- W2281858917 cites W2109865636 @default.
- W2281858917 cites W2118654275 @default.
- W2281858917 cites W2122245900 @default.
- W2281858917 cites W2126503262 @default.
- W2281858917 cites W2127531944 @default.
- W2281858917 cites W2131165482 @default.
- W2281858917 cites W2135338217 @default.
- W2281858917 cites W2160263348 @default.
- W2281858917 cites W2162196135 @default.
- W2281858917 cites W2164627102 @default.
- W2281858917 cites W2170412745 @default.
- W2281858917 cites W2172191543 @default.
- W2281858917 cites W2179796978 @default.
- W2281858917 cites W2221993315 @default.
- W2281858917 cites W2398652404 @default.
- W2281858917 doi "https://doi.org/10.1371/journal.pone.0149775" @default.
- W2281858917 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4766092" @default.
- W2281858917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26909757" @default.
- W2281858917 hasPublicationYear "2016" @default.
- W2281858917 type Work @default.
- W2281858917 sameAs 2281858917 @default.
- W2281858917 citedByCount "14" @default.
- W2281858917 countsByYear W22818589172016 @default.
- W2281858917 countsByYear W22818589172017 @default.
- W2281858917 countsByYear W22818589172018 @default.
- W2281858917 countsByYear W22818589172019 @default.
- W2281858917 countsByYear W22818589172020 @default.
- W2281858917 countsByYear W22818589172021 @default.
- W2281858917 countsByYear W22818589172022 @default.
- W2281858917 countsByYear W22818589172023 @default.
- W2281858917 crossrefType "journal-article" @default.
- W2281858917 hasAuthorship W2281858917A5006427323 @default.
- W2281858917 hasAuthorship W2281858917A5006822602 @default.
- W2281858917 hasAuthorship W2281858917A5026186846 @default.
- W2281858917 hasAuthorship W2281858917A5051762810 @default.
- W2281858917 hasAuthorship W2281858917A5067364038 @default.
- W2281858917 hasBestOaLocation W22818589171 @default.
- W2281858917 hasConcept C126322002 @default.
- W2281858917 hasConcept C16685009 @default.
- W2281858917 hasConcept C185592680 @default.
- W2281858917 hasConcept C203014093 @default.
- W2281858917 hasConcept C2779036427 @default.
- W2281858917 hasConcept C2780076745 @default.
- W2281858917 hasConcept C3018697912 @default.
- W2281858917 hasConcept C43617362 @default.
- W2281858917 hasConcept C54173615 @default.
- W2281858917 hasConcept C55493867 @default.
- W2281858917 hasConcept C71924100 @default.
- W2281858917 hasConcept C7623868 @default.
- W2281858917 hasConcept C89560881 @default.
- W2281858917 hasConceptScore W2281858917C126322002 @default.
- W2281858917 hasConceptScore W2281858917C16685009 @default.