FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2281886115> ?p ?o ?g. }

• W2281886115 abstract "The neuromodulator nitric oxide (NO), in addition to regulating electrophysiological homeostasis, post-synaptic receptor activity, and neuronal functions through cyclic GMP, has recently been shown to modulate the metabolic pathway. NO down-regulates mitochondrial activity [1] and the subsequent increase in AMP facilitates the activation of the phosphofructokinase enzymatic reaction in the glycolytic pathway [2].Given these results, we want to better understand the regulation of neuronal energy metabolism by NO. To do that, we have built a computational model of energy metabolism based on prior works, principally on a model elucidating the control system structures of neuronal metabolism [3] and another highlighting the metabolic role between neuronal activity and hemodynamics [4]. From the first we took the biochemical pathway model, i.e. glycolysis, mitochondrial activity and regulation by the astrocyte to neuron lactate shuttle. From the second we took a model of intracellular sodium concentration and pumping by Na/K-ATPase. We added the activity dependent glutamate cycle [5], driven by electrophysiological activity. We finally completed these models with the previously described modulation by NO.We have new experimental recordings of post synaptic currents in principal cells of the mouse medial nucleus of the trapezoid body (MNTB) in response to high frequency presynaptic stimulation. To match our model to this data we assumed the neurotransmitter released during electrophysiological activity to be proportional to the post synaptic current amplitude and so our glutamate cycle synaptic model, described above, could be related to the recorded EPSC amplitudes. The full metabolism model was then calibrated to match actual voltage clamp MNTB recordings of synapse activity, in the control case and in the presence of 5 mM 2-deoxy-D-glucose, blocking glycolysis, allowing only mitochondrial activity.Model outputs are compared between (1) the baseline (control) conditions, (2) following conditioning with evoked activity that increases NO levels, modifying individually glycolysis and mitochondrial activity, and (3) in full NO regulated conditions, in order to evaluate the individual and mixed metabolism dynamics. Results show that ATP production is slightly increased by NO upregulation of glycolysis (2.5%), significantly increased by mitochondrial inhibition by NO (12.3%) and further increased (15.6%) when both glycolysis and mitochondria are NO modulated.This model will eventually be combined with our previous postsynaptic model that shows NO modulation can reduce the cost of action potential generation in MNTB neurons [6] to build a more complete model of energy consumption during synaptic transmission." @default.
• W2281886115 created "2016-06-24" @default.
• W2281886115 creator A5038313532 @default.
• W2281886115 creator A5043446843 @default.
• W2281886115 creator A5060735528 @default.
• W2281886115 creator A5078698024 @default.
• W2281886115 date "2015-12-01" @default.
• W2281886115 modified "2023-09-27" @default.
• W2281886115 title "Computational modelling predicts activity-dependent neuronal regulation by nitric oxide increases metabolic pathway activity" @default.
• W2281886115 cites W1997551002 @default.
• W2281886115 cites W2018431813 @default.
• W2281886115 cites W2048626265 @default.
• W2281886115 cites W2062126470 @default.
• W2281886115 cites W2078441627 @default.
• W2281886115 cites W2157036180 @default.
• W2281886115 doi "https://doi.org/10.1186/1471-2202-16-s1-p84" @default.
• W2281886115 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4697508" @default.
• W2281886115 hasPublicationYear "2015" @default.
• W2281886115 type Work @default.
• W2281886115 sameAs 2281886115 @default.
• W2281886115 citedByCount "0" @default.
• W2281886115 crossrefType "journal-article" @default.
• W2281886115 hasAuthorship W2281886115A5038313532 @default.
• W2281886115 hasAuthorship W2281886115A5043446843 @default.
• W2281886115 hasAuthorship W2281886115A5060735528 @default.
• W2281886115 hasAuthorship W2281886115A5078698024 @default.
• W2281886115 hasBestOaLocation W22818861151 @default.
• W2281886115 hasConcept C12554922 @default.
• W2281886115 hasConcept C134018914 @default.
• W2281886115 hasConcept C169760540 @default.
• W2281886115 hasConcept C170493617 @default.
• W2281886115 hasConcept C185263204 @default.
• W2281886115 hasConcept C185592680 @default.
• W2281886115 hasConcept C20251656 @default.
• W2281886115 hasConcept C2776219046 @default.
• W2281886115 hasConcept C2777542381 @default.
• W2281886115 hasConcept C519581460 @default.
• W2281886115 hasConcept C529278444 @default.
• W2281886115 hasConcept C55493867 @default.
• W2281886115 hasConcept C61174792 @default.
• W2281886115 hasConcept C62231903 @default.
• W2281886115 hasConcept C74254510 @default.
• W2281886115 hasConcept C86803240 @default.
• W2281886115 hasConcept C95444343 @default.
• W2281886115 hasConceptScore W2281886115C12554922 @default.
• W2281886115 hasConceptScore W2281886115C134018914 @default.
• W2281886115 hasConceptScore W2281886115C169760540 @default.
• W2281886115 hasConceptScore W2281886115C170493617 @default.
• W2281886115 hasConceptScore W2281886115C185263204 @default.
• W2281886115 hasConceptScore W2281886115C185592680 @default.
• W2281886115 hasConceptScore W2281886115C20251656 @default.
• W2281886115 hasConceptScore W2281886115C2776219046 @default.
• W2281886115 hasConceptScore W2281886115C2777542381 @default.
• W2281886115 hasConceptScore W2281886115C519581460 @default.
• W2281886115 hasConceptScore W2281886115C529278444 @default.
• W2281886115 hasConceptScore W2281886115C55493867 @default.
• W2281886115 hasConceptScore W2281886115C61174792 @default.
• W2281886115 hasConceptScore W2281886115C62231903 @default.
• W2281886115 hasConceptScore W2281886115C74254510 @default.
• W2281886115 hasConceptScore W2281886115C86803240 @default.
• W2281886115 hasConceptScore W2281886115C95444343 @default.
• W2281886115 hasLocation W22818861151 @default.
• W2281886115 hasLocation W22818861152 @default.
• W2281886115 hasLocation W22818861153 @default.
• W2281886115 hasOpenAccess W2281886115 @default.
• W2281886115 hasPrimaryLocation W22818861151 @default.
• W2281886115 hasRelatedWork W11142877 @default.
• W2281886115 hasRelatedWork W1561845266 @default.
• W2281886115 hasRelatedWork W1968546385 @default.
• W2281886115 hasRelatedWork W1992338716 @default.
• W2281886115 hasRelatedWork W2008338464 @default.
• W2281886115 hasRelatedWork W2022442596 @default.
• W2281886115 hasRelatedWork W2050492453 @default.
• W2281886115 hasRelatedWork W2055558472 @default.
• W2281886115 hasRelatedWork W2068584514 @default.
• W2281886115 hasRelatedWork W2073537229 @default.
• W2281886115 hasRelatedWork W2091851815 @default.
• W2281886115 hasRelatedWork W2143525505 @default.
• W2281886115 hasRelatedWork W2613490019 @default.
• W2281886115 hasRelatedWork W2743956465 @default.
• W2281886115 hasRelatedWork W2918151311 @default.
• W2281886115 hasRelatedWork W2942764308 @default.
• W2281886115 hasRelatedWork W2981341658 @default.
• W2281886115 hasRelatedWork W3036984864 @default.
• W2281886115 hasRelatedWork W3198722843 @default.
• W2281886115 hasRelatedWork W2122456142 @default.
• W2281886115 isParatext "false" @default.
• W2281886115 isRetracted "false" @default.
• W2281886115 magId "2281886115" @default.
• W2281886115 workType "article" @default.