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- W2282014872 abstract "The efficacy of neonatal blood derived from diabetes-resistant mice to reverse autoimmune diabetes was evaluated in NOD mice under irradiation-free and immunosuppression-free conditions. Transfusion of allogeneic neonatal blood containing Sca-1+ pluripotential stem/progenitor cells significantly delayed the onset and incidence of diabetes. Neonatal blood transfusion also reduced the mononuclear cell infiltration of the islets of Langerhans. Flow cytometry and RT-PCR analysis revealed the induction of chimerism in neonatal blood transfused NOD mice. Splenocytes from most cured NOD mice failed to transfer diabetes into immunodeficient NODscid mice, indicating deletion/suppression of diabetogenic T cells in transfused mice. Protection afforded by neonatal blood transfusion was not simply due to alterations in T regulatory subsets. Splenic T cells from both cured and unprotected mice that received neonatal blood transfusion proliferated poorly and produced lower amounts of IL-2 and IL-17A when challenged with allogeneic antigens in vitro. These data indicate that neonatal blood transfusion can serve as a novel strategy to induce lymphoid chimerism, T cell tolerance and deletion/suppression of diabetogenic T cells in the absence of cytoreduction or costimulatory blockade." @default.
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- W2282014872 date "2008-03-01" @default.
- W2282014872 modified "2023-09-24" @default.
- W2282014872 title "Allogeneic neonatal blood transfusion without recipient preconditioning is a novel strategy to treat autoimmune diabetes in NOD mice" @default.
- W2282014872 doi "https://doi.org/10.1096/fasebj.22.1_supplement.669.24" @default.
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