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- W2282034295 abstract "Several organic anions have been shown to accumulate in the ciliary body following intraocular injection. Additionally, clearance of organic anions from the eye is slowed by the organic anion transport inhibitor probenecid. Here, we hypothesized that the ciliary body epithelium would support organic anion secretion in an aqueous humor (AH)-to-blood direction. Bovine ciliary body epithelium was mounted in Ussing chambers for determination of unidirectional 3H-p-aminohippurate (PAH) fluxes under short-circuited conditions (at 0.01 mM PAH). The unidirectional AH-to-blood flux was 6-fold greater than the blood-to-AH flux (0.6 ± 0.15 vs. 0.1 ± 0.03 nmoles x cm−2 x hr−1), indicating net active secretion. Net active PAH secretion was strongly inhibited by 0.25 mM probenecid. Consistent with the transport data, mRNA (RT-PCR) and protein (Western blot) analysis revealed several organic anion transporters, including OAT1, MRP2 and MRP4 in the ciliary body. Active organic anion secretion (AH-to-blood) by the ciliary body epithelium may influence the effectiveness of thereaputic drugs, such as antivirals, antibiotics and chemotherapeutics, to treat ocular diseases. Supported by NIH (EY006915)." @default.
- W2282034295 created "2016-06-24" @default.
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- W2282034295 date "2009-04-01" @default.
- W2282034295 modified "2023-09-23" @default.
- W2282034295 title "Organic Anion Secretion across the Ciliary Body Epithelium of the Eye" @default.
- W2282034295 doi "https://doi.org/10.1096/fasebj.23.1_supplement.797.9" @default.
- W2282034295 hasPublicationYear "2009" @default.
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