FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2282164829> ?p ?o ?g. }

• W2282164829 endingPage "361" @default.
• W2282164829 startingPage "350" @default.
• W2282164829 abstract "The methylation status of the O(6)-methylguanine-DNA methyltransferase (MGMT) gene is an important predictive biomarker for benefit from alkylating agent therapy in glioblastoma. Our model MGMT-STP27 allows prediction of the methylation status of the MGMT promoter using data from the Illumina's Human Methylation BeadChips (HM-27K and HM-450K) that is publically available for many cancer data sets. Here, we investigate the impact of the context of genetic and epigenetic alterations and tumor type on the classification and report on technical aspects, such as robustness of cutoff definition and preprocessing of the data. The association between gene copy number variation, predicted MGMT methylation, and MGMT expression revealed a gene dosage effect on MGMT expression in lower grade glioma (World Health Organization grade II/III) that in contrast to glioblastoma usually carry two copies of chromosome 10 on which MGMT resides (10q26.3). This implies some MGMT expression, potentially conferring residual repair function blunting the therapeutic effect of alkylating agents. A sensitivity analyses corroborated the performance of the original cutoff for various optimization criteria and for most data preprocessing methods. Finally, we propose an R package mgmtstp27 that allows prediction of the methylation status of the MGMT promoter and calculation of appropriate confidence and/or prediction intervals. Overall, MGMT-STP27 is a robust model for MGMT classification that is independent of tumor type and is adapted for single sample prediction." @default.
• W2282164829 created "2016-06-24" @default.
• W2282164829 creator A5048627921 @default.
• W2282164829 creator A5075134142 @default.
• W2282164829 creator A5078722669 @default.
• W2282164829 date "2016-05-01" @default.
• W2282164829 modified "2023-10-09" @default.
• W2282164829 title "Sensitivity Analysis of the MGMT-STP27 Model and Impact of Genetic and Epigenetic Context to Predict the MGMT Methylation Status in Gliomas and Other Tumors" @default.
• W2282164829 cites W1812256879 @default.
• W2282164829 cites W1829632160 @default.
• W2282164829 cites W1882913614 @default.
• W2282164829 cites W1966099645 @default.
• W2282164829 cites W1985108072 @default.
• W2282164829 cites W1988397485 @default.
• W2282164829 cites W1988756388 @default.
• W2282164829 cites W1989969436 @default.
• W2282164829 cites W1997882134 @default.
• W2282164829 cites W2011570504 @default.
• W2282164829 cites W2013682516 @default.
• W2282164829 cites W2018819214 @default.
• W2282164829 cites W2025183726 @default.
• W2282164829 cites W2031193040 @default.
• W2282164829 cites W2053154970 @default.
• W2282164829 cites W2056040742 @default.
• W2282164829 cites W2069283104 @default.
• W2282164829 cites W2069289315 @default.
• W2282164829 cites W2075358688 @default.
• W2282164829 cites W2078640192 @default.
• W2282164829 cites W2078972833 @default.
• W2282164829 cites W2081093887 @default.
• W2282164829 cites W2081182312 @default.
• W2282164829 cites W2096020932 @default.
• W2282164829 cites W2096681571 @default.
• W2282164829 cites W2101870168 @default.
• W2282164829 cites W2102227900 @default.
• W2282164829 cites W2105100844 @default.
• W2282164829 cites W2105528101 @default.
• W2282164829 cites W2107731988 @default.
• W2282164829 cites W2109816625 @default.
• W2282164829 cites W2116401585 @default.
• W2282164829 cites W2121625674 @default.
• W2282164829 cites W2128130893 @default.
• W2282164829 cites W2131860315 @default.
• W2282164829 cites W2133174470 @default.
• W2282164829 cites W2136895197 @default.
• W2282164829 cites W2138336030 @default.
• W2282164829 cites W2139731590 @default.
• W2282164829 cites W2141713919 @default.
• W2282164829 cites W2142188858 @default.
• W2282164829 cites W2145489645 @default.
• W2282164829 cites W2152575748 @default.
• W2282164829 cites W2154526619 @default.
• W2282164829 cites W2155722648 @default.
• W2282164829 cites W2155881146 @default.
• W2282164829 cites W2163466967 @default.
• W2282164829 cites W2165438710 @default.
• W2282164829 cites W2171418517 @default.
• W2282164829 cites W2470514536 @default.
• W2282164829 cites W2801358783 @default.
• W2282164829 cites W571060166 @default.
• W2282164829 doi "https://doi.org/10.1016/j.jmoldx.2015.11.009" @default.
• W2282164829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26927331" @default.
• W2282164829 hasPublicationYear "2016" @default.
• W2282164829 type Work @default.
• W2282164829 sameAs 2282164829 @default.
• W2282164829 citedByCount "74" @default.
• W2282164829 countsByYear W22821648292016 @default.
• W2282164829 countsByYear W22821648292017 @default.
• W2282164829 countsByYear W22821648292018 @default.
• W2282164829 countsByYear W22821648292019 @default.
• W2282164829 countsByYear W22821648292020 @default.
• W2282164829 countsByYear W22821648292021 @default.
• W2282164829 countsByYear W22821648292022 @default.
• W2282164829 countsByYear W22821648292023 @default.
• W2282164829 crossrefType "journal-article" @default.
• W2282164829 hasAuthorship W2282164829A5048627921 @default.
• W2282164829 hasAuthorship W2282164829A5075134142 @default.
• W2282164829 hasAuthorship W2282164829A5078722669 @default.
• W2282164829 hasBestOaLocation W22821648291 @default.
• W2282164829 hasConcept C104317684 @default.
• W2282164829 hasConcept C150194340 @default.
• W2282164829 hasConcept C151730666 @default.
• W2282164829 hasConcept C190727270 @default.
• W2282164829 hasConcept C2777389519 @default.
• W2282164829 hasConcept C2778227246 @default.
• W2282164829 hasConcept C2779343474 @default.
• W2282164829 hasConcept C2779527866 @default.
• W2282164829 hasConcept C33288867 @default.
• W2282164829 hasConcept C41091548 @default.
• W2282164829 hasConcept C54355233 @default.
• W2282164829 hasConcept C60644358 @default.
• W2282164829 hasConcept C70721500 @default.
• W2282164829 hasConcept C86803240 @default.
• W2282164829 hasConcept C91965660 @default.
• W2282164829 hasConceptScore W2282164829C104317684 @default.
• W2282164829 hasConceptScore W2282164829C150194340 @default.
• W2282164829 hasConceptScore W2282164829C151730666 @default.
• W2282164829 hasConceptScore W2282164829C190727270 @default.

• next