Matches in SemOpenAlex for { <https://semopenalex.org/work/W2282199683> ?p ?o ?g. }
- W2282199683 endingPage "56" @default.
- W2282199683 startingPage "845" @default.
- W2282199683 abstract "Separate 24-h maternal and fetal infusions of valproic acid (VPA) were administered to five pregnant sheep at 125 to 138 days gestation (term approximately 145 days) to determine maternal-fetal disposition. The pharmacokinetics of VPA were also investigated in five newborn 1-day-old lambs after a 6-h drug infusion. Plasma, urine, and amniotic and fetal tracheal fluid samples were analyzed for VPA using gas chromatography-mass spectrometry. During maternal drug infusion, the average steady-state fetal/maternal unbound VPA plasma concentration ratio was 0.81 +/- 0.09. Unbound maternal-to-fetal VPA placental clearance (69.0 +/- 20.2 ml/min/kg) was similar to that in the other direction (61.9 +/- 24.2 ml/min/kg); this indicates passive placental diffusion and intermediate placental permeability of VPA in sheep. Newborn unbound VPA clearance (0.66 +/- 0.28 ml/min/kg) was much lower than in the mother (5.4 +/- 2.7 ml/min/kg) or the fetus (62.1 +/- 22.4 ml/min/kg), and exhibited pronounced Michaelis-Menten characteristics. The elimination half-life of the drug was much longer in the newborn (18.6 +/- 2.6 h) relative to the mother (5.6 +/- 1.4 h) and the fetus (4.6 +/- 1.9 h). Thus, VPA elimination in newborn lambs is much slower as compared with adult sheep, a situation similar to that in humans. Plasma protein binding of VPA was saturable, with similar VPA binding capacities and affinities in maternal and fetal plasma. VPA was extensively displaced from binding sites in the newborn lamb during the first 1 to 2 days of life, possibly because of increased plasma free fatty acid concentrations at birth. Thereafter, newborn plasma appeared to have a similar VPA binding capacity but lower affinity compared with the mother and the fetus." @default.
- W2282199683 created "2016-06-24" @default.
- W2282199683 creator A5006218365 @default.
- W2282199683 creator A5014894665 @default.
- W2282199683 creator A5024370142 @default.
- W2282199683 creator A5039856363 @default.
- W2282199683 creator A5054168920 @default.
- W2282199683 creator A5077832787 @default.
- W2282199683 date "2000-07-01" @default.
- W2282199683 modified "2023-09-29" @default.
- W2282199683 title "Disposition of valproic acid in maternal, fetal, and newborn sheep. I: placental transfer, plasma protein binding, and clearance." @default.
- W2282199683 cites W118420769 @default.
- W2282199683 cites W1527926648 @default.
- W2282199683 cites W1847273820 @default.
- W2282199683 cites W1860946146 @default.
- W2282199683 cites W1904401657 @default.
- W2282199683 cites W1965705920 @default.
- W2282199683 cites W1970590914 @default.
- W2282199683 cites W1974184081 @default.
- W2282199683 cites W1978951742 @default.
- W2282199683 cites W1991279551 @default.
- W2282199683 cites W1991459603 @default.
- W2282199683 cites W1995277155 @default.
- W2282199683 cites W2011469995 @default.
- W2282199683 cites W2024132705 @default.
- W2282199683 cites W2061302257 @default.
- W2282199683 cites W2066771414 @default.
- W2282199683 cites W2070205418 @default.
- W2282199683 cites W2071115523 @default.
- W2282199683 cites W2080108728 @default.
- W2282199683 cites W2080113362 @default.
- W2282199683 cites W2091962839 @default.
- W2282199683 cites W2092412436 @default.
- W2282199683 cites W2103335083 @default.
- W2282199683 cites W2107253712 @default.
- W2282199683 cites W2151295299 @default.
- W2282199683 cites W2154346953 @default.
- W2282199683 cites W2170407184 @default.
- W2282199683 cites W2193177257 @default.
- W2282199683 cites W2209248032 @default.
- W2282199683 cites W2266042311 @default.
- W2282199683 cites W2303777159 @default.
- W2282199683 cites W2310150496 @default.
- W2282199683 cites W2396568161 @default.
- W2282199683 cites W2404394801 @default.
- W2282199683 cites W2407960313 @default.
- W2282199683 cites W2408876184 @default.
- W2282199683 cites W2412878348 @default.
- W2282199683 cites W2423866597 @default.
- W2282199683 cites W2438359498 @default.
- W2282199683 cites W2461167316 @default.
- W2282199683 cites W281384251 @default.
- W2282199683 cites W74649421 @default.
- W2282199683 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10859159" @default.
- W2282199683 hasPublicationYear "2000" @default.
- W2282199683 type Work @default.
- W2282199683 sameAs 2282199683 @default.
- W2282199683 citedByCount "6" @default.
- W2282199683 countsByYear W22821996832013 @default.
- W2282199683 countsByYear W22821996832015 @default.
- W2282199683 crossrefType "journal-article" @default.
- W2282199683 hasAuthorship W2282199683A5006218365 @default.
- W2282199683 hasAuthorship W2282199683A5014894665 @default.
- W2282199683 hasAuthorship W2282199683A5024370142 @default.
- W2282199683 hasAuthorship W2282199683A5039856363 @default.
- W2282199683 hasAuthorship W2282199683A5054168920 @default.
- W2282199683 hasAuthorship W2282199683A5077832787 @default.
- W2282199683 hasConcept C112705442 @default.
- W2282199683 hasConcept C118552586 @default.
- W2282199683 hasConcept C126322002 @default.
- W2282199683 hasConcept C134018914 @default.
- W2282199683 hasConcept C146543888 @default.
- W2282199683 hasConcept C172680121 @default.
- W2282199683 hasConcept C185592680 @default.
- W2282199683 hasConcept C2776953305 @default.
- W2282199683 hasConcept C2777172819 @default.
- W2282199683 hasConcept C2778186239 @default.
- W2282199683 hasConcept C2778194526 @default.
- W2282199683 hasConcept C2779234561 @default.
- W2282199683 hasConcept C2780026642 @default.
- W2282199683 hasConcept C46973012 @default.
- W2282199683 hasConcept C54355233 @default.
- W2282199683 hasConcept C71924100 @default.
- W2282199683 hasConcept C86803240 @default.
- W2282199683 hasConcept C98274493 @default.
- W2282199683 hasConceptScore W2282199683C112705442 @default.
- W2282199683 hasConceptScore W2282199683C118552586 @default.
- W2282199683 hasConceptScore W2282199683C126322002 @default.
- W2282199683 hasConceptScore W2282199683C134018914 @default.
- W2282199683 hasConceptScore W2282199683C146543888 @default.
- W2282199683 hasConceptScore W2282199683C172680121 @default.
- W2282199683 hasConceptScore W2282199683C185592680 @default.
- W2282199683 hasConceptScore W2282199683C2776953305 @default.
- W2282199683 hasConceptScore W2282199683C2777172819 @default.
- W2282199683 hasConceptScore W2282199683C2778186239 @default.
- W2282199683 hasConceptScore W2282199683C2778194526 @default.
- W2282199683 hasConceptScore W2282199683C2779234561 @default.
- W2282199683 hasConceptScore W2282199683C2780026642 @default.