Matches in SemOpenAlex for { <https://semopenalex.org/work/W2282653670> ?p ?o ?g. }
- W2282653670 endingPage "220" @default.
- W2282653670 startingPage "209" @default.
- W2282653670 abstract "A series of 29 pyrimidines comprising analogues of 6-azauridine (e.g. 2- and 4-thio-6-azauridine), 6-substituted uridines (including several known inhibitors of orotidine 5′-monophosphate decarboxylase, ODCase, e.g. pyrazofurin), and 6-azauridine-5′-(ethyl methoxyalaninyl) phosphate (a potential prodrug of 6-AU-5′-MP) were synthesized and evaluated in vitro and in vivo against five RNA viruses: Japanese encephalitis (JE), yellow fever (YF), sandfly fever (SF), Punta Tora (PT) and Venezuelan equine encephalomyelitis (VEE) viruses. 2-Thio-6-azauridine demonstrated the best In vitro activity against all five viruses. However, in vivo activity was not observed in JE-, PT- and VEE-infected mice. The phosphate prodrug of 6-azauridine was significantly more effective than the parent compound in the PT virus mouse model. Optimum in vivo dose/route/schedule was determined for pyrazofurin in PT-virus-infected mice." @default.
- W2282653670 created "2016-06-24" @default.
- W2282653670 creator A5014016854 @default.
- W2282653670 creator A5014937966 @default.
- W2282653670 creator A5015499415 @default.
- W2282653670 creator A5021791082 @default.
- W2282653670 creator A5022335128 @default.
- W2282653670 creator A5027623984 @default.
- W2282653670 creator A5031975164 @default.
- W2282653670 creator A5055066987 @default.
- W2282653670 creator A5073029110 @default.
- W2282653670 creator A5073758478 @default.
- W2282653670 creator A5074182580 @default.
- W2282653670 creator A5074924224 @default.
- W2282653670 creator A5078883561 @default.
- W2282653670 creator A5082510781 @default.
- W2282653670 creator A5082996108 @default.
- W2282653670 creator A5091756526 @default.
- W2282653670 creator A5090065523 @default.
- W2282653670 date "1994-08-01" @default.
- W2282653670 modified "2023-09-26" @default.
- W2282653670 title "<i>In vitro</i>and<i>in vivo</i>antiviral (RNA) evaluation of orotidine 5′-monophosphate decarboxylase inhibitors and analogues including 6-azauridine-5′-(ethyl methoxyalaninyl)phosphate (a 5′-monophosphate prodrug)" @default.
- W2282653670 cites W1242399120 @default.
- W2282653670 cites W1516607153 @default.
- W2282653670 cites W1546322377 @default.
- W2282653670 cites W1855183715 @default.
- W2282653670 cites W1976683819 @default.
- W2282653670 cites W1978252580 @default.
- W2282653670 cites W1981521667 @default.
- W2282653670 cites W1984014058 @default.
- W2282653670 cites W1984221606 @default.
- W2282653670 cites W1988955910 @default.
- W2282653670 cites W1992134901 @default.
- W2282653670 cites W1992976919 @default.
- W2282653670 cites W1994991797 @default.
- W2282653670 cites W1996506600 @default.
- W2282653670 cites W2015141538 @default.
- W2282653670 cites W2015845113 @default.
- W2282653670 cites W2020904878 @default.
- W2282653670 cites W2036707802 @default.
- W2282653670 cites W2042497728 @default.
- W2282653670 cites W2043025795 @default.
- W2282653670 cites W2048069674 @default.
- W2282653670 cites W2049845558 @default.
- W2282653670 cites W2053414783 @default.
- W2282653670 cites W2059834804 @default.
- W2282653670 cites W2060239134 @default.
- W2282653670 cites W2062619457 @default.
- W2282653670 cites W2063825413 @default.
- W2282653670 cites W2063994632 @default.
- W2282653670 cites W2064721260 @default.
- W2282653670 cites W2076506267 @default.
- W2282653670 cites W2078607728 @default.
- W2282653670 cites W2083961167 @default.
- W2282653670 cites W2086801105 @default.
- W2282653670 cites W2091852166 @default.
- W2282653670 cites W2092348839 @default.
- W2282653670 cites W2114867636 @default.
- W2282653670 cites W2268317514 @default.
- W2282653670 cites W2952775781 @default.
- W2282653670 cites W4210994783 @default.
- W2282653670 cites W4211099569 @default.
- W2282653670 cites W81742268 @default.
- W2282653670 cites W1970973521 @default.
- W2282653670 cites W2028085674 @default.
- W2282653670 cites W2086948599 @default.
- W2282653670 doi "https://doi.org/10.1177/095632029400500402" @default.
- W2282653670 hasPublicationYear "1994" @default.
- W2282653670 type Work @default.
- W2282653670 sameAs 2282653670 @default.
- W2282653670 citedByCount "16" @default.
- W2282653670 countsByYear W22826536702012 @default.
- W2282653670 countsByYear W22826536702014 @default.
- W2282653670 countsByYear W22826536702018 @default.
- W2282653670 countsByYear W22826536702022 @default.
- W2282653670 countsByYear W22826536702023 @default.
- W2282653670 crossrefType "journal-article" @default.
- W2282653670 hasAuthorship W2282653670A5014016854 @default.
- W2282653670 hasAuthorship W2282653670A5014937966 @default.
- W2282653670 hasAuthorship W2282653670A5015499415 @default.
- W2282653670 hasAuthorship W2282653670A5021791082 @default.
- W2282653670 hasAuthorship W2282653670A5022335128 @default.
- W2282653670 hasAuthorship W2282653670A5027623984 @default.
- W2282653670 hasAuthorship W2282653670A5031975164 @default.
- W2282653670 hasAuthorship W2282653670A5055066987 @default.
- W2282653670 hasAuthorship W2282653670A5073029110 @default.
- W2282653670 hasAuthorship W2282653670A5073758478 @default.
- W2282653670 hasAuthorship W2282653670A5074182580 @default.
- W2282653670 hasAuthorship W2282653670A5074924224 @default.
- W2282653670 hasAuthorship W2282653670A5078883561 @default.
- W2282653670 hasAuthorship W2282653670A5082510781 @default.
- W2282653670 hasAuthorship W2282653670A5082996108 @default.
- W2282653670 hasAuthorship W2282653670A5090065523 @default.
- W2282653670 hasAuthorship W2282653670A5091756526 @default.
- W2282653670 hasConcept C108215921 @default.
- W2282653670 hasConcept C150903083 @default.
- W2282653670 hasConcept C185592680 @default.
- W2282653670 hasConcept C202751555 @default.