Matches in SemOpenAlex for { <https://semopenalex.org/work/W2282673778> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2282673778 abstract "Surviving infection requires a careful balance of pro-inflammatory signals that promote pathogen clearance and anti-inflammatory signals that prevent immunopathology. The activation and expansion of regulatory T cells (Treg) is key to this balance. FoxP3+ Treg have been shown to acquire certain characteristics of effector T cells when activated in polarized immune responses, expressing Tbet during a Th1 infection and acquiring GATA3 expression during a Th2 response. It is controversial whether these new transcription factors are evidence of conversion to pro-inflammatory effector T cells, or are a mechanism by which the Treg become adapted to their environment and acquire enhanced suppressive function. We have observed that, during respiratory infection with Influenza A virus, approximately 30% of FoxP3+ Treg expressed the potent immunosuppressive cytokine, IL-10. All of the IL-10+ Tregs were also positive for Tbet. Our hypothesis is that the same cytokine signals needed for the induction of IL-10 are also responsible for the initiation of Tbet expression, suggesting that the adaption of Treg cells to their environment facilitates better immunosuppression. We will examine the effects of IL-12, IL-27 and other inflammatory signals on the Tbet expression, IL-10 production and suppressive function of FoxP3+ Tregs both in vitro and in vivo. Our data will elucidate the molecular signals required for optimal disease protection by FoxP3 Tregs in vivo." @default.
- W2282673778 created "2016-06-24" @default.
- W2282673778 creator A5009890616 @default.
- W2282673778 creator A5051465616 @default.
- W2282673778 creator A5061475560 @default.
- W2282673778 creator A5067361267 @default.
- W2282673778 date "2015-11-01" @default.
- W2282673778 modified "2023-09-24" @default.
- W2282673778 title "ID: 250" @default.
- W2282673778 doi "https://doi.org/10.1016/j.cyto.2015.08.253" @default.
- W2282673778 hasPublicationYear "2015" @default.
- W2282673778 type Work @default.
- W2282673778 sameAs 2282673778 @default.
- W2282673778 citedByCount "0" @default.
- W2282673778 crossrefType "journal-article" @default.
- W2282673778 hasAuthorship W2282673778A5009890616 @default.
- W2282673778 hasAuthorship W2282673778A5051465616 @default.
- W2282673778 hasAuthorship W2282673778A5061475560 @default.
- W2282673778 hasAuthorship W2282673778A5067361267 @default.
- W2282673778 hasConcept C104317684 @default.
- W2282673778 hasConcept C203014093 @default.
- W2282673778 hasConcept C207001950 @default.
- W2282673778 hasConcept C2778690821 @default.
- W2282673778 hasConcept C2779727006 @default.
- W2282673778 hasConcept C2780252810 @default.
- W2282673778 hasConcept C51785407 @default.
- W2282673778 hasConcept C54355233 @default.
- W2282673778 hasConcept C86339819 @default.
- W2282673778 hasConcept C86803240 @default.
- W2282673778 hasConcept C8891405 @default.
- W2282673778 hasConcept C95444343 @default.
- W2282673778 hasConceptScore W2282673778C104317684 @default.
- W2282673778 hasConceptScore W2282673778C203014093 @default.
- W2282673778 hasConceptScore W2282673778C207001950 @default.
- W2282673778 hasConceptScore W2282673778C2778690821 @default.
- W2282673778 hasConceptScore W2282673778C2779727006 @default.
- W2282673778 hasConceptScore W2282673778C2780252810 @default.
- W2282673778 hasConceptScore W2282673778C51785407 @default.
- W2282673778 hasConceptScore W2282673778C54355233 @default.
- W2282673778 hasConceptScore W2282673778C86339819 @default.
- W2282673778 hasConceptScore W2282673778C86803240 @default.
- W2282673778 hasConceptScore W2282673778C8891405 @default.
- W2282673778 hasConceptScore W2282673778C95444343 @default.
- W2282673778 hasLocation W22826737781 @default.
- W2282673778 hasOpenAccess W2282673778 @default.
- W2282673778 hasPrimaryLocation W22826737781 @default.
- W2282673778 hasRelatedWork W123872481 @default.
- W2282673778 hasRelatedWork W1932716106 @default.
- W2282673778 hasRelatedWork W2008271242 @default.
- W2282673778 hasRelatedWork W2012989963 @default.
- W2282673778 hasRelatedWork W2079614406 @default.
- W2282673778 hasRelatedWork W2084705440 @default.
- W2282673778 hasRelatedWork W2093276391 @default.
- W2282673778 hasRelatedWork W2124002196 @default.
- W2282673778 hasRelatedWork W2755575514 @default.
- W2282673778 hasRelatedWork W2766901706 @default.
- W2282673778 hasRelatedWork W2768338741 @default.
- W2282673778 hasRelatedWork W2787708566 @default.
- W2282673778 hasRelatedWork W2900346469 @default.
- W2282673778 hasRelatedWork W2921671942 @default.
- W2282673778 hasRelatedWork W2940283232 @default.
- W2282673778 hasRelatedWork W2990307798 @default.
- W2282673778 hasRelatedWork W2998740485 @default.
- W2282673778 hasRelatedWork W3049571397 @default.
- W2282673778 hasRelatedWork W52170494 @default.
- W2282673778 hasRelatedWork W813983228 @default.
- W2282673778 isParatext "false" @default.
- W2282673778 isRetracted "false" @default.
- W2282673778 magId "2282673778" @default.
- W2282673778 workType "article" @default.