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• W2282677897 abstract "We evaluated cellular metabolism profiles of HIV-1 and HIV-2 infected primary human monocyte-derived macrophages (MDMs). First, HIV-2 GL-AN displays faster production kinetics and greater amounts of virus as compared to HIV-1s: YU-2, 89.6 and JR-CSF. Second, quantitative LC–MS/MS metabolomics analysis demonstrates very similar metabolic profiles in glycolysis and TCA cycle metabolic intermediates between HIV-1 and HIV-2 infected macrophages, with a few notable exceptions. The most striking metabolic change in MDMs infected with HIV-2 relative to HIV-1-infected MDMs was the increased levels of quinolinate, a metabolite in the tryptophan catabolism pathway that has been linked to HIV/AIDS pathogenesis. Third, both HIV-1 and HIV-2 infected MDMs showed elevated levels of ribose-5-phosphate, a key metabolic component in nucleotide biosynthesis. Finally, HIV-2 infected MDMs display increased dNTP concentrations as predicted by Vpx-mediated SAMHD1 degradation. Collectively, these data show differential metabolic changes during HIV-1 and HIV-2 infection of macrophages." @default.
• W2282677897 created "2016-06-24" @default.
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• W2282677897 date "2016-04-01" @default.
• W2282677897 modified "2023-10-18" @default.
• W2282677897 title "Metabolic profiling during HIV-1 and HIV-2 infection of primary human monocyte-derived macrophages" @default.
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• W2282677897 doi "https://doi.org/10.1016/j.virol.2016.01.023" @default.
• W2282677897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4834987" @default.
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• W2282677897 hasPublicationYear "2016" @default.
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