Matches in SemOpenAlex for { <https://semopenalex.org/work/W2282830546> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2282830546 endingPage "27" @default.
- W2282830546 startingPage "11" @default.
- W2282830546 abstract "In 1902 William Bayliss and Ernest Starling discovered secretin and it was the beginning of general endocrinology as well as, endocrinology of gastrointestinal tract. Ernest Starling was also a first person who introduced a term hormone for the substances which serves to transfer the information between cells of organism. Subsequent years delivered discovery of successive hormones of the digestive tract. Gastrin was discovered in 1905; whereas cholecystokinin in 1928. Ghrelin and obestatin are last hormones determined in the gastrointestinal tract and they were found in 1999 and 2006, respectively. Both above hormones are originating from the common prohormone. In 60s of past century, the biochemical structure of the gastrointestinal tract hormones was determined for the first time. Substantial progress in endocrinology of the digestive tract took place when radioimmunoassay was employed to measure of hormones concentration. Subsequently, radiolabeled hormones were used to localize hormonal receptors. Next breakthrough in the gastrointestinal tract endocrinology happened after introduction to experimental methods the cloning of complementary DNA. This method has allowed, among the others, to establish the full structure of receptors as well as, a genes coding hormones and their receptors. Discovery of genes structure allowed subsequently introducing these genes into foreign cells, what gives a chance to obtain significant amount of recombined hormones possessing species specificity. This review is presenting a history of the gastrointestinal tract endocrinology, as well as a relevance of gastrointestinal tract hormones in the regulation of body physiological activity." @default.
- W2282830546 created "2016-06-24" @default.
- W2282830546 creator A5052407385 @default.
- W2282830546 creator A5089627000 @default.
- W2282830546 creator A5090819846 @default.
- W2282830546 date "2015-02-01" @default.
- W2282830546 modified "2023-10-18" @default.
- W2282830546 title "Peptidyl hormones of endocrine cells origin in the gut--their discovery and physiological relevance." @default.
- W2282830546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25716961" @default.
- W2282830546 hasPublicationYear "2015" @default.
- W2282830546 type Work @default.
- W2282830546 sameAs 2282830546 @default.
- W2282830546 citedByCount "31" @default.
- W2282830546 countsByYear W22828305462015 @default.
- W2282830546 countsByYear W22828305462016 @default.
- W2282830546 countsByYear W22828305462017 @default.
- W2282830546 countsByYear W22828305462018 @default.
- W2282830546 countsByYear W22828305462019 @default.
- W2282830546 countsByYear W22828305462020 @default.
- W2282830546 countsByYear W22828305462021 @default.
- W2282830546 countsByYear W22828305462022 @default.
- W2282830546 countsByYear W22828305462023 @default.
- W2282830546 crossrefType "journal-article" @default.
- W2282830546 hasAuthorship W2282830546A5052407385 @default.
- W2282830546 hasAuthorship W2282830546A5089627000 @default.
- W2282830546 hasAuthorship W2282830546A5090819846 @default.
- W2282830546 hasConcept C103395026 @default.
- W2282830546 hasConcept C126322002 @default.
- W2282830546 hasConcept C134018914 @default.
- W2282830546 hasConcept C170493617 @default.
- W2282830546 hasConcept C2776986829 @default.
- W2282830546 hasConcept C2777593968 @default.
- W2282830546 hasConcept C2778677841 @default.
- W2282830546 hasConcept C2778764654 @default.
- W2282830546 hasConcept C2779357093 @default.
- W2282830546 hasConcept C2780090379 @default.
- W2282830546 hasConcept C2780512811 @default.
- W2282830546 hasConcept C2781146222 @default.
- W2282830546 hasConcept C46699223 @default.
- W2282830546 hasConcept C49039625 @default.
- W2282830546 hasConcept C56191518 @default.
- W2282830546 hasConcept C71315377 @default.
- W2282830546 hasConcept C71924100 @default.
- W2282830546 hasConcept C86803240 @default.
- W2282830546 hasConceptScore W2282830546C103395026 @default.
- W2282830546 hasConceptScore W2282830546C126322002 @default.
- W2282830546 hasConceptScore W2282830546C134018914 @default.
- W2282830546 hasConceptScore W2282830546C170493617 @default.
- W2282830546 hasConceptScore W2282830546C2776986829 @default.
- W2282830546 hasConceptScore W2282830546C2777593968 @default.
- W2282830546 hasConceptScore W2282830546C2778677841 @default.
- W2282830546 hasConceptScore W2282830546C2778764654 @default.
- W2282830546 hasConceptScore W2282830546C2779357093 @default.
- W2282830546 hasConceptScore W2282830546C2780090379 @default.
- W2282830546 hasConceptScore W2282830546C2780512811 @default.
- W2282830546 hasConceptScore W2282830546C2781146222 @default.
- W2282830546 hasConceptScore W2282830546C46699223 @default.
- W2282830546 hasConceptScore W2282830546C49039625 @default.
- W2282830546 hasConceptScore W2282830546C56191518 @default.
- W2282830546 hasConceptScore W2282830546C71315377 @default.
- W2282830546 hasConceptScore W2282830546C71924100 @default.
- W2282830546 hasConceptScore W2282830546C86803240 @default.
- W2282830546 hasIssue "1" @default.
- W2282830546 hasLocation W22828305461 @default.
- W2282830546 hasOpenAccess W2282830546 @default.
- W2282830546 hasPrimaryLocation W22828305461 @default.
- W2282830546 hasRelatedWork W1490786118 @default.
- W2282830546 hasRelatedWork W165137274 @default.
- W2282830546 hasRelatedWork W2008460537 @default.
- W2282830546 hasRelatedWork W2045388802 @default.
- W2282830546 hasRelatedWork W2087113239 @default.
- W2282830546 hasRelatedWork W2282830546 @default.
- W2282830546 hasRelatedWork W2324197635 @default.
- W2282830546 hasRelatedWork W2415943230 @default.
- W2282830546 hasRelatedWork W2471366604 @default.
- W2282830546 hasRelatedWork W2605595291 @default.
- W2282830546 hasVolume "66" @default.
- W2282830546 isParatext "false" @default.
- W2282830546 isRetracted "false" @default.
- W2282830546 magId "2282830546" @default.
- W2282830546 workType "article" @default.