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- W2282870713 abstract "The canonical Wnt signaling pathway is a stem cell developmental pathway that is active during embryogenesis, and is required for adult tissue homeostasis. The pathway plays a key role in stem cell renewal and regulates epithelial-to-mesenchymal transitions. The pathway is mediated by the intracellular transducer β-catenin and the tumor suppressor adenomatosis polyposis coli. Deregulation of the canonical Wnt pathway is associated with cancer formation and progression, and consequently, inhibitors along multiple points within the Wnt pathway have been sought. Furthermore, inhibitors of the canonical Wnt pathway can also be applied to regenerative medicine. This chapter provides an overview of the current state of canonical Wnt pathway biology and small-molecule inhibitors of the pathway." @default.
- W2282870713 created "2016-06-24" @default.
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- W2282870713 date "2012-01-01" @default.
- W2282870713 modified "2023-09-25" @default.
- W2282870713 title "Recent Advances in Wnt/β-Catenin Pathway Small-Molecule Inhibitors" @default.
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- W2282870713 doi "https://doi.org/10.1016/b978-0-12-396492-2.00026-6" @default.
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