FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2282883256> ?p ?o ?g. }

• W2282883256 endingPage "156" @default.
• W2282883256 startingPage "144" @default.
• W2282883256 abstract "Advances in solid drug nanoparticle technologies have resulted in a number of long-acting (LA) formulations with the potential for once monthly or longer administration. Such formulations offer great utility for chronic diseases, particularly when a lack of medication compliance may be detrimental to treatment response. Two such formulations are in clinical development for HIV but the concept of LA delivery has its origins in indications such as schizophrenia and contraception. Many terms have been utilised to describe the LA approach and standardisation would be beneficial. Ultimately, definitions will depend upon specific indications and routes of delivery, but for HIV we propose benchmarks that reflect perceived clinical benefits and available data on patient attitudes. Specifically, we propose dosing intervals of ≥1week, ≥1month or ≥6months, for oral, injectable or implantable strategies, respectively. This review focuses upon the critical importance of potency in achieving the LA outcome for injectable formulations and explores established and emerging technologies that have been employed across indications. Key technological challenges such as the need for consistency and ease of administration for drug combinations, are also discussed. Finally, the review explores the gaps in knowledge regarding the pharmacology of drug release from particulate-based LA injectable suspensions. A number of hypotheses are discussed based upon available data relating to local drug metabolism, active transport systems, the lymphatics, macrophages and patient-specific factors. Greater knowledge of the mechanisms that underpin drug release and protracted exposure will help facilitate further development of this strategy to achieve the promising clinical benefits." @default.
• W2282883256 created "2016-06-24" @default.
• W2282883256 creator A5022406499 @default.
• W2282883256 creator A5066429649 @default.
• W2282883256 date "2016-08-01" @default.
• W2282883256 modified "2023-10-17" @default.
• W2282883256 title "Strengths, weaknesses, opportunities and challenges for long acting injectable therapies: Insights for applications in HIV therapy" @default.
• W2282883256 cites W1264540065 @default.
• W2282883256 cites W1490484843 @default.
• W2282883256 cites W153550834 @default.
• W2282883256 cites W1576188396 @default.
• W2282883256 cites W1583251544 @default.
• W2282883256 cites W1668080676 @default.
• W2282883256 cites W1674196795 @default.
• W2282883256 cites W1797316917 @default.
• W2282883256 cites W1866224665 @default.
• W2282883256 cites W1965354305 @default.
• W2282883256 cites W1967035954 @default.
• W2282883256 cites W1967781227 @default.
• W2282883256 cites W1971198904 @default.
• W2282883256 cites W1972764294 @default.
• W2282883256 cites W1972885668 @default.
• W2282883256 cites W1978329829 @default.
• W2282883256 cites W1978349904 @default.
• W2282883256 cites W1979240595 @default.
• W2282883256 cites W1982502053 @default.
• W2282883256 cites W1983491788 @default.
• W2282883256 cites W1984548348 @default.
• W2282883256 cites W1984582997 @default.
• W2282883256 cites W1984704903 @default.
• W2282883256 cites W1985772998 @default.
• W2282883256 cites W1988663341 @default.
• W2282883256 cites W1990609423 @default.
• W2282883256 cites W1991714414 @default.
• W2282883256 cites W1992155535 @default.
• W2282883256 cites W1996083965 @default.
• W2282883256 cites W1996773895 @default.
• W2282883256 cites W1997059257 @default.
• W2282883256 cites W2001929658 @default.
• W2282883256 cites W2002564282 @default.
• W2282883256 cites W2004639120 @default.
• W2282883256 cites W2007358452 @default.
• W2282883256 cites W2007539416 @default.
• W2282883256 cites W2007793290 @default.
• W2282883256 cites W2014233890 @default.
• W2282883256 cites W2014863810 @default.
• W2282883256 cites W2016558849 @default.
• W2282883256 cites W2021386451 @default.
• W2282883256 cites W2024823439 @default.
• W2282883256 cites W2026003216 @default.
• W2282883256 cites W2028262396 @default.
• W2282883256 cites W2029198995 @default.
• W2282883256 cites W2032480902 @default.
• W2282883256 cites W2032501421 @default.
• W2282883256 cites W2035899858 @default.
• W2282883256 cites W2036169249 @default.
• W2282883256 cites W2036443620 @default.
• W2282883256 cites W2038317671 @default.
• W2282883256 cites W2038480928 @default.
• W2282883256 cites W2040872150 @default.
• W2282883256 cites W2041934694 @default.
• W2282883256 cites W2042274093 @default.
• W2282883256 cites W2044716063 @default.
• W2282883256 cites W2047241207 @default.
• W2282883256 cites W2047699078 @default.
• W2282883256 cites W2048641572 @default.
• W2282883256 cites W2049259580 @default.
• W2282883256 cites W2050309886 @default.
• W2282883256 cites W2051772157 @default.
• W2282883256 cites W2052373664 @default.
• W2282883256 cites W2052480807 @default.
• W2282883256 cites W2052761374 @default.
• W2282883256 cites W2054323958 @default.
• W2282883256 cites W2054512362 @default.
• W2282883256 cites W2054745605 @default.
• W2282883256 cites W2056424254 @default.
• W2282883256 cites W2057527788 @default.
• W2282883256 cites W2057584545 @default.
• W2282883256 cites W2057687190 @default.
• W2282883256 cites W2061009479 @default.
• W2282883256 cites W2063219873 @default.
• W2282883256 cites W2064045930 @default.
• W2282883256 cites W2064140898 @default.
• W2282883256 cites W206710202 @default.
• W2282883256 cites W2067496453 @default.
• W2282883256 cites W2067554343 @default.
• W2282883256 cites W2069853594 @default.
• W2282883256 cites W2071955492 @default.
• W2282883256 cites W2075756716 @default.
• W2282883256 cites W2078877172 @default.
• W2282883256 cites W2086612854 @default.
• W2282883256 cites W2088662584 @default.
• W2282883256 cites W2090030079 @default.
• W2282883256 cites W2090298778 @default.
• W2282883256 cites W2091950497 @default.
• W2282883256 cites W2092409560 @default.
• W2282883256 cites W2104051674 @default.
• W2282883256 cites W2104822546 @default.

• next