FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2282912644> ?p ?o ?g. }

• W2282912644 endingPage "7096" @default.
• W2282912644 startingPage "7087" @default.
• W2282912644 abstract "Hox genes play a pivotal role in the determination of anteroposterior axis specificity during bilaterian animal development. They do so by acting as a master control and regulating the expression of genes important for development. Recently, however, we showed that Hox genes can also function in terminally differentiated tissue of the lepidopteran Bombyx mori. In this species, Antennapedia (Antp) regulates expression of sericin-1, a major silk protein gene, in the silk gland. Here, we investigated whether Antp can regulate expression of multiple genes in this tissue. By means of proteomic, RT-PCR, and in situ hybridization analyses, we demonstrate that misexpression of Antp in the posterior silk gland induced ectopic expression of major silk protein genes such as sericin-3, fhxh4, and fhxh5. These genes are normally expressed specifically in the middle silk gland as is Antp. Therefore, the evidence strongly suggests that Antp activates these silk protein genes in the middle silk gland. The putative sericin-1 activator complex (middle silk gland-intermolt-specific complex) can bind to the upstream regions of these genes, suggesting that Antp directly activates their expression. We also found that the pattern of gene expression was well conserved between B. mori and the wild species Bombyx mandarina, indicating that the gene regulation mechanism identified here is an evolutionarily conserved mechanism and not an artifact of the domestication of B. mori. We suggest that Hox genes have a role as a master control in terminally differentiated tissues, possibly acting as a primary regulator for a range of physiological processes. Hox genes play a pivotal role in the determination of anteroposterior axis specificity during bilaterian animal development. They do so by acting as a master control and regulating the expression of genes important for development. Recently, however, we showed that Hox genes can also function in terminally differentiated tissue of the lepidopteran Bombyx mori. In this species, Antennapedia (Antp) regulates expression of sericin-1, a major silk protein gene, in the silk gland. Here, we investigated whether Antp can regulate expression of multiple genes in this tissue. By means of proteomic, RT-PCR, and in situ hybridization analyses, we demonstrate that misexpression of Antp in the posterior silk gland induced ectopic expression of major silk protein genes such as sericin-3, fhxh4, and fhxh5. These genes are normally expressed specifically in the middle silk gland as is Antp. Therefore, the evidence strongly suggests that Antp activates these silk protein genes in the middle silk gland. The putative sericin-1 activator complex (middle silk gland-intermolt-specific complex) can bind to the upstream regions of these genes, suggesting that Antp directly activates their expression. We also found that the pattern of gene expression was well conserved between B. mori and the wild species Bombyx mandarina, indicating that the gene regulation mechanism identified here is an evolutionarily conserved mechanism and not an artifact of the domestication of B. mori. We suggest that Hox genes have a role as a master control in terminally differentiated tissues, possibly acting as a primary regulator for a range of physiological processes." @default.
• W2282912644 created "2016-06-24" @default.
• W2282912644 creator A5011338005 @default.
• W2282912644 creator A5031815471 @default.
• W2282912644 creator A5042772189 @default.
• W2282912644 creator A5048175681 @default.
• W2282912644 creator A5077977761 @default.
• W2282912644 creator A5080756133 @default.
• W2282912644 creator A5083794408 @default.
• W2282912644 creator A5083888735 @default.
• W2282912644 date "2016-03-01" @default.
• W2282912644 modified "2023-10-18" @default.
• W2282912644 title "A Hox Gene, Antennapedia, Regulates Expression of Multiple Major Silk Protein Genes in the Silkworm Bombyx mori" @default.
• W2282912644 cites W1605418718 @default.
• W2282912644 cites W1962832013 @default.
• W2282912644 cites W1976116914 @default.
• W2282912644 cites W1979659675 @default.
• W2282912644 cites W1981593008 @default.
• W2282912644 cites W1989467089 @default.
• W2282912644 cites W1991458360 @default.
• W2282912644 cites W1991680585 @default.
• W2282912644 cites W1994784181 @default.
• W2282912644 cites W2006788765 @default.
• W2282912644 cites W2011525708 @default.
• W2282912644 cites W2011855140 @default.
• W2282912644 cites W2017449525 @default.
• W2282912644 cites W2023035275 @default.
• W2282912644 cites W2027968607 @default.
• W2282912644 cites W2030669108 @default.
• W2282912644 cites W2030917322 @default.
• W2282912644 cites W2033623874 @default.
• W2282912644 cites W2034728925 @default.
• W2282912644 cites W2035881414 @default.
• W2282912644 cites W2043032007 @default.
• W2282912644 cites W2051718568 @default.
• W2282912644 cites W2055601111 @default.
• W2282912644 cites W2056066578 @default.
• W2282912644 cites W2069013215 @default.
• W2282912644 cites W2074557012 @default.
• W2282912644 cites W2076914475 @default.
• W2282912644 cites W2080935664 @default.
• W2282912644 cites W2083714644 @default.
• W2282912644 cites W2084828902 @default.
• W2282912644 cites W2084850666 @default.
• W2282912644 cites W2100202282 @default.
• W2282912644 cites W2111341106 @default.
• W2282912644 cites W2120093164 @default.
• W2282912644 cites W2120240537 @default.
• W2282912644 cites W2131672533 @default.
• W2282912644 cites W2165457864 @default.
• W2282912644 cites W2168907400 @default.
• W2282912644 cites W2218155435 @default.
• W2282912644 cites W4241303123 @default.
• W2282912644 doi "https://doi.org/10.1074/jbc.m115.699819" @default.
• W2282912644 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4807290" @default.
• W2282912644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26814126" @default.
• W2282912644 hasPublicationYear "2016" @default.
• W2282912644 type Work @default.
• W2282912644 sameAs 2282912644 @default.
• W2282912644 citedByCount "15" @default.
• W2282912644 countsByYear W22829126442016 @default.
• W2282912644 countsByYear W22829126442017 @default.
• W2282912644 countsByYear W22829126442019 @default.
• W2282912644 countsByYear W22829126442020 @default.
• W2282912644 countsByYear W22829126442021 @default.
• W2282912644 countsByYear W22829126442022 @default.
• W2282912644 countsByYear W22829126442023 @default.
• W2282912644 crossrefType "journal-article" @default.
• W2282912644 hasAuthorship W2282912644A5011338005 @default.
• W2282912644 hasAuthorship W2282912644A5031815471 @default.
• W2282912644 hasAuthorship W2282912644A5042772189 @default.
• W2282912644 hasAuthorship W2282912644A5048175681 @default.
• W2282912644 hasAuthorship W2282912644A5077977761 @default.
• W2282912644 hasAuthorship W2282912644A5080756133 @default.
• W2282912644 hasAuthorship W2282912644A5083794408 @default.
• W2282912644 hasAuthorship W2282912644A5083888735 @default.
• W2282912644 hasBestOaLocation W22829126441 @default.
• W2282912644 hasConcept C104317684 @default.
• W2282912644 hasConcept C111039654 @default.
• W2282912644 hasConcept C150194340 @default.
• W2282912644 hasConcept C2777126123 @default.
• W2282912644 hasConcept C2778332815 @default.
• W2282912644 hasConcept C2778487026 @default.
• W2282912644 hasConcept C2780172944 @default.
• W2282912644 hasConcept C46751350 @default.
• W2282912644 hasConcept C54355233 @default.
• W2282912644 hasConcept C86803240 @default.
• W2282912644 hasConcept C95444343 @default.
• W2282912644 hasConcept C97037327 @default.
• W2282912644 hasConceptScore W2282912644C104317684 @default.
• W2282912644 hasConceptScore W2282912644C111039654 @default.
• W2282912644 hasConceptScore W2282912644C150194340 @default.
• W2282912644 hasConceptScore W2282912644C2777126123 @default.
• W2282912644 hasConceptScore W2282912644C2778332815 @default.
• W2282912644 hasConceptScore W2282912644C2778487026 @default.
• W2282912644 hasConceptScore W2282912644C2780172944 @default.
• W2282912644 hasConceptScore W2282912644C46751350 @default.
• W2282912644 hasConceptScore W2282912644C54355233 @default.

• next