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• W2282917829 abstract "Vitamin D3 plays an important role in the control of cell proliferation and differentiation. Cholesterol 25-hydroxylase (CH25H) is an enzyme converting cholesterol into 25-hydroxycholesterol. Vitamin D3 as well as 25-hydroxycholesterol has been shown to inhibit cell growth and induce cell apoptosis. Here we show that 10 nM 1a,25(OH)2D3 and 500 nM 25OHD3 upregulate CH25H mRNA expression in human primary prostate stromal cells (P29SN). Protein synthesis inhibitor cycloheximide does not block 1a,25(OH)2D3 mediated upregulation of CH25H mRNA. Transcription inhibitor actinomycin D blocks basal level as well as 1a,25(OH)2D3 induced CH25H mRNA expression. 1a,25(OH)2D3 has no effect on CH25H mRNA stability. 25-Hydroxycholesterol significantly decreased the P29SN cell number. A CH25H enzyme inhibitor, desmosterol, increases basal cell number but has no significant effect on vitamin D3 treated cells. Our data suggest that ch25h could be a vitamin D3 target gene and may partly mediate anti-proliferative action of vitamin D3 in human primary prostate stromal cells. 2006 Elsevier Inc. All rights reserved." @default.
• W2282917829 created "2016-06-24" @default.
• W2282917829 creator A5048407767 @default.
• W2282917829 date "2009-01-01" @default.
• W2282917829 modified "2023-09-27" @default.
• W2282917829 title "Vitamin D, Lipid Metabolism and Prostate Cancer" @default.
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