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- W2283092967 endingPage "149" @default.
- W2283092967 startingPage "137" @default.
- W2283092967 abstract "Soluble guanylyl cyclase (sGC), which produces the second messenger cyclic guanosine 3', 5'-monophosphate (cGMP), is at the crossroads of nitric oxide (NO) signaling: sGC catalytic activity is both stimulated by NO binding to the heme and inhibited by NO modification of its cysteine (Cys) thiols (S-nitrosation). Modulation of sGC activity by thiol oxidation makes sGC a therapeutic target for pathologies originating from oxidative or nitrosative stress. sGC has an unusually high percentage of Cys for a cytosolic protein, the majority solvent exposed and therefore accessible modulatory targets for biological and pathophysiological signaling. Recent Advances: Thiol oxidation of sGC contributes to the development of cardiovascular diseases by decreasing NO-dependent cGMP production and thereby vascular reactivity. This thiol-based resistance to NO (e.g., increase in peripheral resistance) is observed in hypertension and hyperaldosteronism.Some roles of specific Cys thiols have been identified in vitro. So far, it has not been possible to pinpoint the roles of specific Cys of sGC in vivo and to investigate the molecular mechanisms in an animal model.The role of Cys as redox sensors, intermediates of activation, and mediators of change in sGC conformation, activity, and dimerization remains largely unexplored. To understand modulation of sGC activity, it is critical to investigate the roles of specific oxidative thiol modifications that are formed during these processes. Where the redox state of sGC thiols contribute to pathologies (vascular resistance and sGC desensitization by NO donors), it becomes crucial to design therapeutic strategies to restore sGC to its normal, physiological thiol redox state. Antioxid. Redox Signal. 26, 137-149." @default.
- W2283092967 created "2016-06-24" @default.
- W2283092967 creator A5009622144 @default.
- W2283092967 date "2017-01-20" @default.
- W2283092967 modified "2023-10-14" @default.
- W2283092967 title "Thiol-Based Redox Modulation of Soluble Guanylyl Cyclase, the Nitric Oxide Receptor" @default.
- W2283092967 cites W1491886695 @default.
- W2283092967 cites W1512367461 @default.
- W2283092967 cites W1544209968 @default.
- W2283092967 cites W1586374375 @default.
- W2283092967 cites W1599529839 @default.
- W2283092967 cites W1786604115 @default.
- W2283092967 cites W1830067208 @default.
- W2283092967 cites W1867506901 @default.
- W2283092967 cites W1923972005 @default.
- W2283092967 cites W1946927438 @default.
- W2283092967 cites W1964141267 @default.
- W2283092967 cites W1964268123 @default.
- W2283092967 cites W1969341053 @default.
- W2283092967 cites W1970169137 @default.
- W2283092967 cites W1971983381 @default.
- W2283092967 cites W1974611305 @default.
- W2283092967 cites W1975189886 @default.
- W2283092967 cites W1976555160 @default.
- W2283092967 cites W1982203562 @default.
- W2283092967 cites W1982536922 @default.
- W2283092967 cites W1982627444 @default.
- W2283092967 cites W1983094993 @default.
- W2283092967 cites W1984102163 @default.
- W2283092967 cites W1986025894 @default.
- W2283092967 cites W1986623914 @default.
- W2283092967 cites W1989079026 @default.
- W2283092967 cites W1989644067 @default.
- W2283092967 cites W1991592722 @default.
- W2283092967 cites W1992718978 @default.
- W2283092967 cites W1994211699 @default.
- W2283092967 cites W1995788314 @default.
- W2283092967 cites W1996044283 @default.
- W2283092967 cites W1998998834 @default.
- W2283092967 cites W2000075945 @default.
- W2283092967 cites W2004724154 @default.
- W2283092967 cites W2006132439 @default.
- W2283092967 cites W2007737411 @default.
- W2283092967 cites W2009410239 @default.
- W2283092967 cites W2009784881 @default.
- W2283092967 cites W2011595187 @default.
- W2283092967 cites W2014433643 @default.
- W2283092967 cites W2014495816 @default.
- W2283092967 cites W2014822929 @default.
- W2283092967 cites W2015899974 @default.
- W2283092967 cites W2016764124 @default.
- W2283092967 cites W2017651603 @default.
- W2283092967 cites W2018400595 @default.
- W2283092967 cites W2018547798 @default.
- W2283092967 cites W2022972602 @default.
- W2283092967 cites W2028046930 @default.
- W2283092967 cites W2028186012 @default.
- W2283092967 cites W2029452421 @default.
- W2283092967 cites W2030489390 @default.
- W2283092967 cites W2031250144 @default.
- W2283092967 cites W2037574965 @default.
- W2283092967 cites W2038006724 @default.
- W2283092967 cites W2038265634 @default.
- W2283092967 cites W2041301976 @default.
- W2283092967 cites W2041523876 @default.
- W2283092967 cites W2043168997 @default.
- W2283092967 cites W2045441583 @default.
- W2283092967 cites W2046860937 @default.
- W2283092967 cites W2047609920 @default.
- W2283092967 cites W2048550600 @default.
- W2283092967 cites W2054041272 @default.
- W2283092967 cites W2054243540 @default.
- W2283092967 cites W2054935021 @default.
- W2283092967 cites W2056357865 @default.
- W2283092967 cites W2057106948 @default.
- W2283092967 cites W2058289888 @default.
- W2283092967 cites W2060419524 @default.
- W2283092967 cites W2061800171 @default.
- W2283092967 cites W2064860687 @default.
- W2283092967 cites W2065773243 @default.
- W2283092967 cites W2068391586 @default.
- W2283092967 cites W2069373907 @default.
- W2283092967 cites W2069707745 @default.
- W2283092967 cites W2071468228 @default.
- W2283092967 cites W2080674641 @default.
- W2283092967 cites W2081394289 @default.
- W2283092967 cites W2081612114 @default.
- W2283092967 cites W2082605863 @default.
- W2283092967 cites W2083227319 @default.
- W2283092967 cites W2084854699 @default.
- W2283092967 cites W2085094809 @default.
- W2283092967 cites W2088636394 @default.
- W2283092967 cites W2090280224 @default.
- W2283092967 cites W2092110104 @default.
- W2283092967 cites W2098789742 @default.
- W2283092967 cites W2109407919 @default.
- W2283092967 cites W2112413125 @default.
- W2283092967 cites W2113071164 @default.