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- W2283148005 abstract "A 7-year boy with homozygous sickle cell disease, diagnosed at the age of 2, was admitted to hospital complaining of abdominal pain, headache, fever (temperature 38.6 oC) and jaundice. Liver enlargement was detected but the spleen was not palpable. The boy had emigrated from equatorial Guinea 1 month previously. The hemoglobin level was 42 g/L and there was evidence of hemolytic anemia (lactate dehydrogenase: 1023U/L; haptoglobin:<6 mg/dL; reticulocytes: 549,000/mm). Electrophoresis showed a single band of hemoglobin S (Hb S:90.9%), hemoglobin F:4.1% and hemoglobin A2:2.6%, consistent with the presence of hemoglobin SS sickle disease. Examination of a blood smear revealed a high proportion of sickle cells (arrow), erythroblasts (ball and line) and frequent red cells containing Plasmodium falciparum (arrowhead). The patient had no previous history of malaria. Although hemoglobin S is considered to be protective against Plasmodium falciparum, this is not always the case and in this child, the congenital disease complicated the diagnosis of malaria because hemolysis was related to the infection rather than to sickle cell disease." @default.
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- W2283148005 date "2006-01-01" @default.
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- W2283148005 title "Malaria and sickle cell disease" @default.
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