FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2283163602> ?p ?o ?g. }

• W2283163602 endingPage "3024" @default.
• W2283163602 startingPage "3018" @default.
• W2283163602 abstract "Liver tumorigenesis frequently causes insulin resistance which may be used as an independent risk factor for evaluation of survival and post-surgery relapse of liver cancer patients. In the present study, HepG2/IR, an insulin resistant HepG2 cell line, was established by exposing HepG2 cells to 0.5 µmol/l of insulin for 72 h, and comparison of HepG2/IR with the parental HepG2 cells indicated that the HepG2/IR cells showed significantly enhanced resistance to the most frequently used chemotherapeutics for solid tumors, such as cisplatin, 5-fluorouracil, vincristine and mitomycin. Flow cytometric analysis of cisplatin-treated HepG2/IR cells showed a significantly decreased hypodiploid peak and a significantly downregulated expression level of pro-apoptotic protein caspase-3 compared with the parental HepG2 cells. Our data further showed swollen endoplasmic reticulum (ER) in the cisplatin-treated HepG2/IR cells with significantly increased levels of glucose-regulated protein 78 (GRP78), phosphorylated protein kinase R-like ER kinase (p-PERK) and P-glycoprotein (P-gp). There was also an upregulated expression of anti-apoptotic protein B-cell lymphoma 2 (Bcl-2) whereas no significant change was observed for CCAAT-enhancer-binding protein homologous protein (CHOP), which is known to be induced by ER stress and to mediate apoptosis. Our results demonstrated that insulin resistance in HepG2 cells promoted a protective unfolded protein response and upregulated the expression of ER chaperone protein GRP78, which resulted in the phosphorylation of PERK kinase to activate the PERK-mediated ER stress signal transduction pathway and the upregulation of Bcl-2 and P-gp, leading to the inhibition of the caspase-3-dependent apoptosis pathway and to the survival of liver tumor cells." @default.
• W2283163602 created "2016-06-24" @default.
• W2283163602 creator A5004618782 @default.
• W2283163602 creator A5012677271 @default.
• W2283163602 creator A5042235591 @default.
• W2283163602 creator A5048379858 @default.
• W2283163602 creator A5059073200 @default.
• W2283163602 creator A5072925833 @default.
• W2283163602 creator A5077717253 @default.
• W2283163602 creator A5080288244 @default.
• W2283163602 date "2016-02-24" @default.
• W2283163602 modified "2023-10-14" @default.
• W2283163602 title "Insulin resistance contributes to multidrug resistance in HepG2 cells via activation of the PERK signaling pathway and upregulation of Bcl-2 and P-gp" @default.
• W2283163602 cites W1634990876 @default.
• W2283163602 cites W1968604361 @default.
• W2283163602 cites W1969161182 @default.
• W2283163602 cites W1974029497 @default.
• W2283163602 cites W1976353070 @default.
• W2283163602 cites W1980157504 @default.
• W2283163602 cites W1984513597 @default.
• W2283163602 cites W1988778035 @default.
• W2283163602 cites W1989602074 @default.
• W2283163602 cites W1991250346 @default.
• W2283163602 cites W1995734875 @default.
• W2283163602 cites W1996014702 @default.
• W2283163602 cites W2001007571 @default.
• W2283163602 cites W2002707371 @default.
• W2283163602 cites W2010099866 @default.
• W2283163602 cites W2021626729 @default.
• W2283163602 cites W2026986256 @default.
• W2283163602 cites W2031755474 @default.
• W2283163602 cites W2036521927 @default.
• W2283163602 cites W2042654228 @default.
• W2283163602 cites W2048009931 @default.
• W2283163602 cites W2077111508 @default.
• W2283163602 cites W2081481054 @default.
• W2283163602 cites W2084948426 @default.
• W2283163602 cites W2089658873 @default.
• W2283163602 cites W2091197058 @default.
• W2283163602 cites W2092115819 @default.
• W2283163602 cites W2099584899 @default.
• W2283163602 cites W2110458715 @default.
• W2283163602 cites W2115366344 @default.
• W2283163602 cites W2115639274 @default.
• W2283163602 cites W2141100586 @default.
• W2283163602 cites W2169385554 @default.
• W2283163602 cites W2171578490 @default.
• W2283163602 cites W236572111 @default.
• W2283163602 cites W625816070 @default.
• W2283163602 doi "https://doi.org/10.3892/or.2016.4632" @default.
• W2283163602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26935266" @default.
• W2283163602 hasPublicationYear "2016" @default.
• W2283163602 type Work @default.
• W2283163602 sameAs 2283163602 @default.
• W2283163602 citedByCount "14" @default.
• W2283163602 countsByYear W22831636022017 @default.
• W2283163602 countsByYear W22831636022018 @default.
• W2283163602 countsByYear W22831636022019 @default.
• W2283163602 countsByYear W22831636022021 @default.
• W2283163602 countsByYear W22831636022022 @default.
• W2283163602 countsByYear W22831636022023 @default.
• W2283163602 crossrefType "journal-article" @default.
• W2283163602 hasAuthorship W2283163602A5004618782 @default.
• W2283163602 hasAuthorship W2283163602A5012677271 @default.
• W2283163602 hasAuthorship W2283163602A5042235591 @default.
• W2283163602 hasAuthorship W2283163602A5048379858 @default.
• W2283163602 hasAuthorship W2283163602A5059073200 @default.
• W2283163602 hasAuthorship W2283163602A5072925833 @default.
• W2283163602 hasAuthorship W2283163602A5077717253 @default.
• W2283163602 hasAuthorship W2283163602A5080288244 @default.
• W2283163602 hasBestOaLocation W22831636021 @default.
• W2283163602 hasConcept C104317684 @default.
• W2283163602 hasConcept C126322002 @default.
• W2283163602 hasConcept C127561419 @default.
• W2283163602 hasConcept C134018914 @default.
• W2283163602 hasConcept C139447449 @default.
• W2283163602 hasConcept C153911025 @default.
• W2283163602 hasConcept C161238802 @default.
• W2283163602 hasConcept C184235292 @default.
• W2283163602 hasConcept C190283241 @default.
• W2283163602 hasConcept C2778997996 @default.
• W2283163602 hasConcept C29537977 @default.
• W2283163602 hasConcept C502942594 @default.
• W2283163602 hasConcept C55493867 @default.
• W2283163602 hasConcept C62478195 @default.
• W2283163602 hasConcept C71924100 @default.
• W2283163602 hasConcept C82495950 @default.
• W2283163602 hasConcept C86803240 @default.
• W2283163602 hasConcept C95444343 @default.
• W2283163602 hasConcept C97029542 @default.
• W2283163602 hasConceptScore W2283163602C104317684 @default.
• W2283163602 hasConceptScore W2283163602C126322002 @default.
• W2283163602 hasConceptScore W2283163602C127561419 @default.
• W2283163602 hasConceptScore W2283163602C134018914 @default.
• W2283163602 hasConceptScore W2283163602C139447449 @default.
• W2283163602 hasConceptScore W2283163602C153911025 @default.
• W2283163602 hasConceptScore W2283163602C161238802 @default.
• W2283163602 hasConceptScore W2283163602C184235292 @default.

• next