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• W2283215425 endingPage "C1423" @default.
• W2283215425 startingPage "C1417" @default.
• W2283215425 abstract "We examined the effect of peroxynitrite (ONOO − ) on the cloned rat epithelial Na + channel (αβγ-rENaC) expressed in Xenopusoocytes. 3-Morpholinosydnonimine (SIN-1) was used to concurrently generate nitric oxide (⋅ NO) and superoxide ([Formula: see text] ⋅), which react to form ONOO − , a species known to promote protein nitration and oxidation. Under control conditions, oocytes displayed an amiloride-sensitive whole cell conductance of 7.4 ± 2.8 (SE) μS. When incubated at 18°C with SIN-1 (1 mM) for 2 h (final ONOO − concentration = 10 μM), the amiloride-sensitive conductance was reduced to 0.8 ± 0.5 μS. To evaluate whether the observed inhibition was due to ONOO − , as opposed to ⋅ NO, we also exposed oocytes to SIN-1 in the presence of urate (500 μM), a scavenger of ONOO − and superoxide dismutase, which scavenges[Formula: see text] ⋅, converting SIN-1 from an ONOO − to an ⋅ NO donor. Under these conditions, conductance values remained at control levels following SIN-1 treatment. Tetranitromethane, an agent that oxidizes sulfhydryl groups at pH 6, also inhibited the amiloride-sensitive conductance. These data suggest that oxidation of critical sulfhydryl groups within rENaC by ONOO − directly inhibits channel activity." @default.
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• W2283215425 date "1998-05-01" @default.
• W2283215425 modified "2023-10-16" @default.
• W2283215425 title "Peroxynitrite inhibits amiloride-sensitive Na⁺ currents in<i>Xenopus</i> oocytes expressing αβγ-rENaC" @default.
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• W2283215425 doi "https://doi.org/10.1152/ajpcell.1998.274.5.c1417" @default.
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