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- W2283236482 abstract "Background: Chronic heart failure (CHF) and renal impairment frequently coexist. Statins have been evaluated for renoprotective effects in patients with coronary heart disease and dyslipidemia, and atorvastatin has been shown to improve renal function in those patients. However, there is little information available on the effect of atorvastatin on chronic kidney injury in CHF patients. Methods: We enrolled 38 mild to moderate CHF outpatients (NYHA class 1.9±0.6, ischemic origin: 54%) with left ventricular ejection fraction (LVEF) < 40% (28±8%) and serum creatinine < 3.0mg/dl. These patients were randomly assigned to receive atorvastatin (10mg/d) or conventional treatment for heart failure, and were prospectively followed up for at least three years. The measurement of serum creatinine level (sCr) was measured at entry, and repeated every at least 6 month after the entry, and chronic kidney injury (CKI) was defined as an increase of more than 0.3mg/dl in baseline sCr value. Furthermore, the circulating le..." @default.
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- W2283236482 date "2013-11-26" @default.
- W2283236482 modified "2023-09-23" @default.
- W2283236482 title "Abstract 14706: Atorvastatin Would Prevent Chronic Kidney Injury in Patients With Chronic Heart Failure - A Prospective Randomized-Controlled Study -" @default.
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