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- W2283278316 abstract "Although the remission induction of childhood acute lymphoblastic leukemia (ALL) is relatively easy, many patients relapse sometime during their courses. Our past experience (in 1970s) was dismal and we could not attain overall survival of above-50-percent level. To improve the treatment outcome we thought post-remission chemotherapy (“continuation therapy”) is most important. As Skipper showed [1], total leukemic cell kill could be best attained with repeated pulses of sufficiently effective treatment courses. To test this hypothesis and to obtain better treatment outcome, we employed an intermittent intensive continuation therapy. As an interim result from our pilot study of this approach on a small number (n = 20) of patients was satisfactory in attaining over 80 percent relapse free survival at 3 years’ follow-up, we started a group study for childhood ALL in Hiroshima and adjacent areas. Our aim was to obtain near- 100-percent relapse free long-term survival at least in “standard risk” patients. Result of long term follow-up was somewhat disappointing, but proved that the intensive intermittent continuation therapy is one of the useful approaches to improve the treatment outcome of ALL." @default.
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- W2283278316 date "1994-01-01" @default.
- W2283278316 modified "2023-09-23" @default.
- W2283278316 title "Long-Term Follow-Up of a Pilot Study of Intermittent Intensive Continuation Therapy (HL-3 Protocol) for Childhood Acute Lymphoblastic Leukemia" @default.
- W2283278316 cites W1527938262 @default.
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- W2283278316 doi "https://doi.org/10.1007/978-3-642-78350-0_62" @default.
- W2283278316 hasPublicationYear "1994" @default.
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