Matches in SemOpenAlex for { <https://semopenalex.org/work/W2283365461> ?p ?o ?g. }
- W2283365461 endingPage "428" @default.
- W2283365461 startingPage "421" @default.
- W2283365461 abstract "Several genome-wide association studies on breast cancer have reported similar findings of a new cancer susceptibility locus, 8q24 rsl3281615. Subsequent case-control studies have rapidly investigated the association between the single nucleotide polymorphism of rsl3281615 at chromosome 8q24 and breast cancer risk, but the effect of 8q24 rsl3281615 polymorphism on breast cancer is still unclear due to the inconsistence among those studies. Given the contradictory findings, a meta-analysis was performed to determine the association between 8q24 rsl3281615 polymorphism and breast cancer risk. 12 eligible case-control studies with a total of 42,508 cases and 53,928 controls were finally included into this meta-analysis by searching the PubMed, Embase, and China Biology Medicine (CBM) databases. We estimated the summary odds ratio (OR) with its corresponding 95 % confidence interval (95 % CI) to assess this association. Meta-analyses of total 12 studies showed 8q24 rsl3281615 polymorphism was significantly associated with an increased risk of breast cancer in all contrast models (OR(G vs. A) = 1.10, 95 % CI 1.05-1.14, P (OR) < 0.001; OR(GG vs. AA) = 1.20, 95 % CI 1.11-1.29, P (OR) < 0.001; OR(AG vs. AA) = 1.08, 95 % CI 1.05-1.12, P (OR) < 0.001; OR(GG vs. AA +AG) = 1.13, 95 % CI 1.07-1.19, P (OR) < 0.001; OR(GG+AG vs. AA) = 1.13, 95 % CI 1.07-1.19, P (OR) < 0.001). Meta-analyses of studies with high quality showed that 8q24 rsl3281615 polymorphism was still significantly associated with an increased risk of breast cancer under the five genetic contrast models. Sensitivity analyses by sequential omission of any individual studies and subgroup analyses by ethnicity further identified the significant association between 8q24 rsl3281615 polymorphism and breast cancer risk. Conclusively, this meta-analysis shows a significant association between 8q24 rsl3281615 polymorphism and breast cancer risk." @default.
- W2283365461 created "2016-06-24" @default.
- W2283365461 creator A5023128001 @default.
- W2283365461 creator A5060747664 @default.
- W2283365461 creator A5080867678 @default.
- W2283365461 date "2012-11-07" @default.
- W2283365461 modified "2023-09-26" @default.
- W2283365461 title "Polymorphism of 8q24 rsl3281615 and breast cancer risk" @default.
- W2283365461 cites W1987630725 @default.
- W2283365461 cites W1991460649 @default.
- W2283365461 cites W1994664175 @default.
- W2283365461 cites W1995404520 @default.
- W2283365461 cites W1998358624 @default.
- W2283365461 cites W2016141109 @default.
- W2283365461 cites W2030865196 @default.
- W2283365461 cites W2031772624 @default.
- W2283365461 cites W2033339450 @default.
- W2283365461 cites W2054211750 @default.
- W2283365461 cites W2056647439 @default.
- W2283365461 cites W2058363773 @default.
- W2283365461 cites W2062672427 @default.
- W2283365461 cites W2063973520 @default.
- W2283365461 cites W2066504266 @default.
- W2283365461 cites W2107328434 @default.
- W2283365461 cites W2113178124 @default.
- W2283365461 cites W2123153543 @default.
- W2283365461 cites W2125117632 @default.
- W2283365461 cites W2125435699 @default.
- W2283365461 cites W2132055476 @default.
- W2283365461 cites W2156911571 @default.
- W2283365461 cites W2157134953 @default.
- W2283365461 cites W2157823046 @default.
- W2283365461 cites W2168783384 @default.
- W2283365461 cites W2331114446 @default.
- W2283365461 cites W78649709 @default.
- W2283365461 doi "https://doi.org/10.1007/s13277-012-0566-1" @default.
- W2283365461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23132293" @default.
- W2283365461 hasPublicationYear "2012" @default.
- W2283365461 type Work @default.
- W2283365461 sameAs 2283365461 @default.
- W2283365461 citedByCount "8" @default.
- W2283365461 countsByYear W22833654612015 @default.
- W2283365461 countsByYear W22833654612016 @default.
- W2283365461 countsByYear W22833654612019 @default.
- W2283365461 countsByYear W22833654612020 @default.
- W2283365461 countsByYear W22833654612021 @default.
- W2283365461 crossrefType "journal-article" @default.
- W2283365461 hasAuthorship W2283365461A5023128001 @default.
- W2283365461 hasAuthorship W2283365461A5060747664 @default.
- W2283365461 hasAuthorship W2283365461A5080867678 @default.
- W2283365461 hasConcept C104317684 @default.
- W2283365461 hasConcept C121608353 @default.
- W2283365461 hasConcept C126322002 @default.
- W2283365461 hasConcept C135763542 @default.
- W2283365461 hasConcept C143998085 @default.
- W2283365461 hasConcept C146304588 @default.
- W2283365461 hasConcept C153209595 @default.
- W2283365461 hasConcept C156957248 @default.
- W2283365461 hasConcept C29456083 @default.
- W2283365461 hasConcept C44249647 @default.
- W2283365461 hasConcept C530470458 @default.
- W2283365461 hasConcept C54355233 @default.
- W2283365461 hasConcept C71924100 @default.
- W2283365461 hasConcept C86803240 @default.
- W2283365461 hasConcept C90924648 @default.
- W2283365461 hasConcept C95190672 @default.
- W2283365461 hasConceptScore W2283365461C104317684 @default.
- W2283365461 hasConceptScore W2283365461C121608353 @default.
- W2283365461 hasConceptScore W2283365461C126322002 @default.
- W2283365461 hasConceptScore W2283365461C135763542 @default.
- W2283365461 hasConceptScore W2283365461C143998085 @default.
- W2283365461 hasConceptScore W2283365461C146304588 @default.
- W2283365461 hasConceptScore W2283365461C153209595 @default.
- W2283365461 hasConceptScore W2283365461C156957248 @default.
- W2283365461 hasConceptScore W2283365461C29456083 @default.
- W2283365461 hasConceptScore W2283365461C44249647 @default.
- W2283365461 hasConceptScore W2283365461C530470458 @default.
- W2283365461 hasConceptScore W2283365461C54355233 @default.
- W2283365461 hasConceptScore W2283365461C71924100 @default.
- W2283365461 hasConceptScore W2283365461C86803240 @default.
- W2283365461 hasConceptScore W2283365461C90924648 @default.
- W2283365461 hasConceptScore W2283365461C95190672 @default.
- W2283365461 hasIssue "1" @default.
- W2283365461 hasLocation W22833654611 @default.
- W2283365461 hasLocation W22833654612 @default.
- W2283365461 hasOpenAccess W2283365461 @default.
- W2283365461 hasPrimaryLocation W22833654611 @default.
- W2283365461 hasRelatedWork W1996753309 @default.
- W2283365461 hasRelatedWork W2032808049 @default.
- W2283365461 hasRelatedWork W2047252483 @default.
- W2283365461 hasRelatedWork W2099158786 @default.
- W2283365461 hasRelatedWork W2107074164 @default.
- W2283365461 hasRelatedWork W2130475562 @default.
- W2283365461 hasRelatedWork W2286371484 @default.
- W2283365461 hasRelatedWork W2406708134 @default.
- W2283365461 hasRelatedWork W2976179431 @default.
- W2283365461 hasRelatedWork W2991253679 @default.
- W2283365461 hasVolume "34" @default.