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- W2283370947 abstract "Individual differences in impulsivity and early adversity are known to be strong predictors of adolescent antisocial behavior. However, the neurobiological bases of impulsivity and their relation to antisocial behavior and adversity are poorly understood.Impulsivity was estimated with a temporal discounting task. Voxel-based morphometry was used to determine the brain structural correlates of temporal discounting in a large cohort (n = 1830) of 14- to 15-year-old children. Mediation analysis was then used to determine whether the volumes of brain regions associated with temporal discounting mediate the relation between adverse life events (e.g., family conflict, serious accidents) and antisocial behaviors (e.g., precocious sexual activity, bullying, illicit substance use).Greater temporal discounting (more impulsivity) was associated with 1) lower volume in frontomedial cortex and bilateral insula and 2) greater volume in a subcortical region encompassing the ventral striatum, hypothalamus and anterior thalamus. The volume ratio between these cortical and subcortical regions was found to partially mediate the relation between adverse life events and antisocial behavior.Temporal discounting is related to regions of the brain involved in reward processing and interoception. The results support a developmental imbalance model of impulsivity and are consistent with the idea that negative environmental factors can alter the developing brain in ways that promote antisocial behavior." @default.
- W2283370947 created "2016-06-24" @default.
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- W2283370947 date "2017-08-01" @default.
- W2283370947 modified "2023-10-18" @default.
- W2283370947 title "Brain Regions Related to Impulsivity Mediate the Effects of Early Adversity on Antisocial Behavior" @default.
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- W2283370947 doi "https://doi.org/10.1016/j.biopsych.2015.12.027" @default.
- W2283370947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26971049" @default.
- W2283370947 hasPublicationYear "2017" @default.
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