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- W2283448021 abstract "Background:Carcinoma ex pleomorphic adenoma (CXPA) is an aggressive but poorly understood malignancy which usually arises from salivary glands as a primary or recurrent benign pleomorphic adenoma. The clinical presentation and prognosis were not fully investigated, especially in Asian peopleAim and Objectives:To analyze the clinical cases of CXPA in VGHTPE and to investigate the diagnostic difficulties.Materials and Methods:We retrospectively reviewed the medical records over a 12-year period at the academic medical center. 15 patients with the final pathological diagnosis of CXPA were investigated. Special attention was paid to the clinical presentation, preoperative diagnostic tool as well as the survival time.Results:The most common symptom of CXPA was a palpable mass over cheek or neck (100 %). 4 patients (27%) complained of a painful mass, whereas 2 patients (13%) complained of facial nerve palsy and 1 patient (7%) of skin ulceration. The average time from the onset of symptoms to definite diagnosis was 8.3 years. The sensitivity of cytology in detecting CXPA was 57.1% and that of CT was only 23% in our study. During the follow-up time of 43.5 months in average, 7 patients (46.7%) suffered from tumor recurrence and four patients died from the disease. The overall 3-year survival rate was 70% and the 3-year-recurrence-free survival rate was 58%. The malignant surgical margin was related to the tumor recurrence rate. (chi-square = 6.61; p = 0.0102). Patients in tumor stage T1 and T2 have significantly longer survival time compared with those in tumor stage T3 or T4 (chi-square = 10.64; p = 0.013).Conclusion:Preoperative diagnosis of CXPA is very challenging. Compared with computed tomography, fine needle aspiration cytology has higher sensitivity in detecting this tumor. Given that the malignant surgical margin is associated with the tumor recurrence, more accurate preoperative diagnosis assisted by clinical suspicion and FNAC should be advocated." @default.
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- W2283448021 date "2013-03-01" @default.
- W2283448021 modified "2023-09-25" @default.
- W2283448021 title "Carcinoma Ex Pleomorphic Adenoma-Clinical Experience in Taipei Veteran General Hospital" @default.
- W2283448021 hasPublicationYear "2013" @default.
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