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• W2283487189 abstract "Abstract RNAs stored in the metaphase II-arrested oocyte play important roles in successful embryonic development. Their abundance is defined by transcriptional activity during oocyte growth and selective degradation of transcripts during LH-induced oocyte maturation. Our previous studies demonstrated that mRNA abundance is increased in mature ovulated oocytes collected from obese humans and mice and therefore may contribute to reduced oocyte developmental competence associated with metabolic dysfunction. In the current study mouse models of diet-induced obesity were used to determine whether obesity-dependent increases in proinflammatory signaling regulate ovarian abundance of oocyte-specific mRNAs. The abundance of oocyte-specific Bnc1, Dppa3, and Pou5f1 mRNAs as well as markers of proinflammatory signaling were significantly increased in ovaries of obese compared with lean mice which were depleted of fully grown preovulatory follicles. Chromatin-immunoprecipitation analyses also demonstrated increased association of phosphorylated signal transducer and activator of transcription 3 with the Pou5f1 promoter in ovaries of obese mice suggesting that proinflammatory signaling regulates transcription of this gene in the oocyte. The cecum microbial content of lean and obese female mice was subsequently examined to identify potential relationships between microbial composition and proinflammatory signaling in the ovary. Multivariate Association with Linear Models identified significant positive correlations between cecum abundance of the bacterial family Lachnospiraceae and ovarian abundance of Tnfa as well as Dppa3, Bnc1, and Pou5f1 mRNAs. Together, these data suggest that diet-induced changes in gut microbial composition may be contributing to ovarian inflammation which in turn alters ovarian gene expression and ultimately contributes to obesity-dependent reduction in oocyte quality and development of infertility in obese patients." @default.
• W2283487189 created "2016-06-24" @default.
• W2283487189 creator A5034348140 @default.
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• W2283487189 creator A5091573028 @default.
• W2283487189 date "2016-02-16" @default.
• W2283487189 modified "2023-10-10" @default.
• W2283487189 title "Obesity-Dependent Increases in Oocyte mRNAs Are Associated With Increases in Proinflammatory Signaling and Gut Microbial Abundance of Lachnospiraceae in Female Mice" @default.
• W2283487189 cites W1540239684 @default.
• W2283487189 cites W1565469572 @default.
• W2283487189 cites W1577577364 @default.
• W2283487189 cites W1822745879 @default.
• W2283487189 cites W1926323304 @default.
• W2283487189 cites W1968900211 @default.
• W2283487189 cites W1971913712 @default.
• W2283487189 cites W1973981342 @default.
• W2283487189 cites W1975301513 @default.
• W2283487189 cites W1977388404 @default.
• W2283487189 cites W1979431956 @default.
• W2283487189 cites W1979861092 @default.
• W2283487189 cites W1982780418 @default.
• W2283487189 cites W1984741060 @default.
• W2283487189 cites W1987976709 @default.
• W2283487189 cites W1988925586 @default.
• W2283487189 cites W1999586571 @default.
• W2283487189 cites W2002220979 @default.
• W2283487189 cites W2009139889 @default.
• W2283487189 cites W2011044632 @default.
• W2283487189 cites W2011948097 @default.
• W2283487189 cites W2014025975 @default.
• W2283487189 cites W2015814034 @default.
• W2283487189 cites W2021848169 @default.
• W2283487189 cites W2024712071 @default.
• W2283487189 cites W2028511423 @default.
• W2283487189 cites W2040173157 @default.
• W2283487189 cites W2041689291 @default.
• W2283487189 cites W2043371051 @default.
• W2283487189 cites W2046452752 @default.
• W2283487189 cites W2049338857 @default.
• W2283487189 cites W2049676804 @default.
• W2283487189 cites W2049868101 @default.
• W2283487189 cites W2055615060 @default.
• W2283487189 cites W2070261938 @default.
• W2283487189 cites W2071592190 @default.
• W2283487189 cites W2072970694 @default.
• W2283487189 cites W2073332363 @default.
• W2283487189 cites W2078378773 @default.
• W2283487189 cites W2081107312 @default.
• W2283487189 cites W2086648828 @default.
• W2283487189 cites W2088514277 @default.
• W2283487189 cites W2088833470 @default.
• W2283487189 cites W2089111937 @default.
• W2283487189 cites W2097875133 @default.
• W2283487189 cites W2097979496 @default.
• W2283487189 cites W2099087520 @default.
• W2283487189 cites W2101197781 @default.
• W2283487189 cites W2104890139 @default.
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• W2283487189 cites W2108622660 @default.
• W2283487189 cites W2108718991 @default.
• W2283487189 cites W2109586018 @default.
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• W2283487189 cites W2126795310 @default.
• W2283487189 cites W2127500571 @default.
• W2283487189 cites W2128594412 @default.
• W2283487189 cites W2131536322 @default.
• W2283487189 cites W2138819642 @default.
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• W2283487189 doi "https://doi.org/10.1210/en.2015-1851" @default.
• W2283487189 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4816731" @default.
• W2283487189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26881311" @default.
• W2283487189 hasPublicationYear "2016" @default.
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