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- W2283559094 abstract "The presence of mesenchymal progenitor cells within bone marrow has been known since the late nineteenth century. To date, mesenchymal stem cells (MSCs) have been isolated from several different connective tissues, such as adipose tissue, muscle, placenta, umbilical cord matrix, blood, liver, and dental pulp. Bone marrow, however, is still one of the major sources of MSCs for preclinical and clinical research. MSCs were first evaluated for regenerative applications and have since been shown to directly influence the immune system and to promote neovascularization of ischemic tissues. These observations have prompted a new era of MSC transplantation as a treatment for various diseases. In this review, we summarize the important studies that have investigated the use of MSCs as a therapeutic agent for regenerative medicine, immune disorders, cancer, and gene therapy. Furthermore, we discuss the mechanisms involved in MSC-based therapies and clinical-grade MSC manufacturing." @default.
- W2283559094 created "2016-06-24" @default.
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- W2283559094 date "2013-01-01" @default.
- W2283559094 modified "2023-09-25" @default.
- W2283559094 title "Mesenchymal stem cells in tissue repairing and regeneration: Progress and future" @default.
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- W2283559094 doi "https://doi.org/10.4103/2321-3868.113330" @default.
- W2283559094 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4994498" @default.
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