FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2283588324> ?p ?o ?g. }

• W2283588324 endingPage "442" @default.
• W2283588324 startingPage "433" @default.
• W2283588324 abstract "The authors evaluated all available evidence on the use of propofol as an adjuvant for the treatment of resistant alcohol withdrawal syndrome (AWS) in comparison to other therapies. A comprehensive PubMed search (1966-December 2015) was conducted using the search terms propofol, alcohol withdrawal, and drug therapy. Articles were cross-referenced for other citations. Clinical studies, case series, and case reports published in the English language assessing the use of propofol in adult patients for treatment of AWS were reviewed for inclusion. Propofol is a sedative-hypnotic that exerts its actions through agonism of GABAA receptors at a different binding site than benzodiazepines and reduces glutamatergic activity through N-methyl-d-aspartase (NMDA) receptor blockade. Dosages from 5 to 100 μg/kg/minute reduced AWS symptoms with frequent development of hypotension and requirement for mechanical ventilation. Patients on propofol often experienced longer durations of mechanical ventilation and length of stay, which may be attributed to more-resistant cases of AWS. When propofol was compared with dexmedetomidine as adjuncts in AWS, both agents showed similar benzodiazepine- and haloperidol-sparing effects. Dexmedetomidine was associated with more numerical rates of bradycardia, while propofol was associated with more numerical instances of hypotension. Dexmedetomidine was used more frequently in nonintubated patients. The available data assessing the utility of propofol for AWS exhibited significant heterogeneity. Propofol may be useful in a specific population of patients with AWS, limited to those who are not clinically responding to first-line therapy with benzodiazepines. Specifically, propofol should be considered in patients who are refractory to or not candidates for other adjuvant therapies, patients already requiring mechanical ventilation, or those with seizure activity or refractory delirium tremens. In severe, refractory AWS, adjuvant therapy with propofol may be considered but requires further research to recommend its use either preferentially or as monotherapy." @default.
• W2283588324 created "2016-06-24" @default.
• W2283588324 creator A5018852444 @default.
• W2283588324 creator A5035647810 @default.
• W2283588324 creator A5036974967 @default.
• W2283588324 creator A5088042984 @default.
• W2283588324 date "2016-04-01" @default.
• W2283588324 modified "2023-10-05" @default.
• W2283588324 title "Propofol for Treatment of Refractory Alcohol Withdrawal Syndrome: A Review of the Literature" @default.
• W2283588324 cites W1587162888 @default.
• W2283588324 cites W1747187494 @default.
• W2283588324 cites W1971563329 @default.
• W2283588324 cites W1971742645 @default.
• W2283588324 cites W1989131846 @default.
• W2283588324 cites W1992298385 @default.
• W2283588324 cites W1992614879 @default.
• W2283588324 cites W1993430659 @default.
• W2283588324 cites W2001660166 @default.
• W2283588324 cites W2001918477 @default.
• W2283588324 cites W2010309142 @default.
• W2283588324 cites W2019252062 @default.
• W2283588324 cites W2022549176 @default.
• W2283588324 cites W2024018065 @default.
• W2283588324 cites W2026891160 @default.
• W2283588324 cites W2028471588 @default.
• W2283588324 cites W2030728791 @default.
• W2283588324 cites W2033134182 @default.
• W2283588324 cites W2034871979 @default.
• W2283588324 cites W2037199501 @default.
• W2283588324 cites W2044898423 @default.
• W2283588324 cites W2045287322 @default.
• W2283588324 cites W2050326473 @default.
• W2283588324 cites W2057032421 @default.
• W2283588324 cites W2059915772 @default.
• W2283588324 cites W2060198298 @default.
• W2283588324 cites W2066376216 @default.
• W2283588324 cites W2078974586 @default.
• W2283588324 cites W2099271696 @default.
• W2283588324 cites W2120161689 @default.
• W2283588324 cites W2123282949 @default.
• W2283588324 cites W2123705832 @default.
• W2283588324 cites W2125866389 @default.
• W2283588324 cites W2138725067 @default.
• W2283588324 cites W2139956889 @default.
• W2283588324 cites W2143780481 @default.
• W2283588324 cites W2145236099 @default.
• W2283588324 cites W2161785561 @default.
• W2283588324 cites W2166055854 @default.
• W2283588324 cites W2204514959 @default.
• W2283588324 cites W4247665917 @default.
• W2283588324 doi "https://doi.org/10.1002/phar.1726" @default.
• W2283588324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26893017" @default.
• W2283588324 hasPublicationYear "2016" @default.
• W2283588324 type Work @default.
• W2283588324 sameAs 2283588324 @default.
• W2283588324 citedByCount "32" @default.
• W2283588324 countsByYear W22835883242017 @default.
• W2283588324 countsByYear W22835883242018 @default.
• W2283588324 countsByYear W22835883242019 @default.
• W2283588324 countsByYear W22835883242020 @default.
• W2283588324 countsByYear W22835883242021 @default.
• W2283588324 countsByYear W22835883242022 @default.
• W2283588324 countsByYear W22835883242023 @default.
• W2283588324 crossrefType "journal-article" @default.
• W2283588324 hasAuthorship W2283588324A5018852444 @default.
• W2283588324 hasAuthorship W2283588324A5035647810 @default.
• W2283588324 hasAuthorship W2283588324A5036974967 @default.
• W2283588324 hasAuthorship W2283588324A5088042984 @default.
• W2283588324 hasConcept C126322002 @default.
• W2283588324 hasConcept C170493617 @default.
• W2283588324 hasConcept C185592680 @default.
• W2283588324 hasConcept C2776277131 @default.
• W2283588324 hasConcept C2776814716 @default.
• W2283588324 hasConcept C2777602617 @default.
• W2283588324 hasConcept C2778173252 @default.
• W2283588324 hasConcept C2780873584 @default.
• W2283588324 hasConcept C2781066024 @default.
• W2283588324 hasConcept C2781302539 @default.
• W2283588324 hasConcept C2908647359 @default.
• W2283588324 hasConcept C42219234 @default.
• W2283588324 hasConcept C55493867 @default.
• W2283588324 hasConcept C71924100 @default.
• W2283588324 hasConcept C99454951 @default.
• W2283588324 hasConceptScore W2283588324C126322002 @default.
• W2283588324 hasConceptScore W2283588324C170493617 @default.
• W2283588324 hasConceptScore W2283588324C185592680 @default.
• W2283588324 hasConceptScore W2283588324C2776277131 @default.
• W2283588324 hasConceptScore W2283588324C2776814716 @default.
• W2283588324 hasConceptScore W2283588324C2777602617 @default.
• W2283588324 hasConceptScore W2283588324C2778173252 @default.
• W2283588324 hasConceptScore W2283588324C2780873584 @default.
• W2283588324 hasConceptScore W2283588324C2781066024 @default.
• W2283588324 hasConceptScore W2283588324C2781302539 @default.
• W2283588324 hasConceptScore W2283588324C2908647359 @default.
• W2283588324 hasConceptScore W2283588324C42219234 @default.
• W2283588324 hasConceptScore W2283588324C55493867 @default.
• W2283588324 hasConceptScore W2283588324C71924100 @default.
• W2283588324 hasConceptScore W2283588324C99454951 @default.

• next