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- W2283636516 abstract "Two methods were assessed for the generation of common N-heterocyclic carbenes (NHCs) from stable imidazol(in)ium precursors using convenient and straightforward continuous-flow setups with either a heterogeneous inorganic base (Cs2CO3 or K3PO4) or a homogeneous organic base (KN(SiMe3)2). In-line quenching with carbon disulfide revealed that the homogeneous strategy was most efficient for the preparation of a small library of NHCs. The generation of free nucleophilic carbenes was next telescoped with two benchmark NHC-catalyzed reactions; namely, the transesterification of vinyl acetate with benzyl alcohol and the amidation of N-Boc-glycine methyl ester with ethanolamine. Both organocatalytic transformations proceeded with total conversion and excellent yields were achieved after extraction, showcasing the first examples of continuous-flow organocatalysis with NHCs." @default.
- W2283636516 created "2016-06-24" @default.
- W2283636516 creator A5005723932 @default.
- W2283636516 creator A5039864499 @default.
- W2283636516 creator A5053067902 @default.
- W2283636516 creator A5068422233 @default.
- W2283636516 date "2016-02-16" @default.
- W2283636516 modified "2023-09-26" @default.
- W2283636516 title "Continuous-Flow N-Heterocyclic Carbene Generation and Organocatalysis" @default.
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- W2283636516 doi "https://doi.org/10.1002/chem.201505135" @default.
- W2283636516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26880372" @default.
- W2283636516 hasPublicationYear "2016" @default.
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