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- W2283647573 abstract "e15644 Background: We investigated current practices and their relative abilities to effectively screen for and detect bone metastases (mets). It is unknown what percentage of HCC bone mets are blastic versus lytic, and what imaging modality best identifies them. Methods: We retrospectively assessed all adults diagnosed with HCC at our center from 1/1997 - 8/2008. Primary outcomes were the percentage of lytic lesions, and the sensitivity and specificity of bone scans in detecting bone mets. Results: 462 patients were included. Mean age at diagnosis was 60 years; 80% were male, and hepatitis C was the most common etiology of HCC (58%). 54% of all patients received bone scans. 67% were considered diagnostic, whereas the remaining scans required a confirmatory test(s) (23% PET, 41% plain X-ray, 54% CT, and 10% MRI). 5% of all patients were diagnosed with bone mets (n=24), of which 42% were diagnosed at presentation, 20% during continued follow-up, and 38% during post-operative surveillance. 96% of all bone lesions were lytic, of which 13% were undetected by bone scan (sensitivity = 79%, specificity = 98%). None of the lesions were blastic and 4% remained indeterminate after independent review with an attending bone radiologist. Of those patients who underwent resection or liver transplantation (n=205) 35 patients recurred (31% with bone recurrence and 6% with bone mets as their only site of disease). Within this surgical group, patients with bone mets only had higher 1,3,and 5 year survival rates compared to patients with other extrahepatic lesions, although only significant for 3 year survival (p=0.013). 4 of the 24 patients with bone mets received a biopsy. All 4 confirmed metastatic HCC. Conclusions: Due to the high specificity, bone scans serve as a good initial screening test to rule out bone mets in the HCC population. However in populations at higher risk of presenting with bone mets (post-tranplantation/resection) a more sensitive test may be needed. Additional studies are warranted to determine whether other modalities, such as PET/CT or skeletal survey, are more sensitive tests for the detection of bone mets. No significant financial relationships to disclose." @default.
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- W2283647573 date "2009-05-20" @default.
- W2283647573 modified "2023-10-01" @default.
- W2283647573 title "Radiologic detection of bone metastasis in patients with hepatocellular carcinoma: A single-center experience" @default.
- W2283647573 doi "https://doi.org/10.1200/jco.2009.27.15_suppl.e15644" @default.
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