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• W2283656568 startingPage "E380" @default.
• W2283656568 abstract "The molecular basis for variations in resting metabolic rate (RMR) within a species is unknown. One possibility is that variations in RMR occur because of variations in uncoupling protein 2 (UCP-2) and uncoupling protein 3 (UCP-3) expression, resulting in mitochondrial proton leak differences. We tested the hypothesis that UCP-2 and -3 mRNAs positively correlate with RMR and proton leak. We treated thyroidectomized and sham-operated mice with triiodothyronine (T 3 ) or vehicle and measured RMR, liver, and skeletal muscle mitochondrial nonphosphorylating respiration and UCP-2 and -3 mRNAs. T 3 stimulated RMR and liver UCP-2 and gastrocnemius UCP-2 and -3 expression. Mitochondrial respiration was not affected by T 3 and did not correlate with UCP-2 and -3 mRNAs. Gastrocnemius UCP-2 and -3 expression did correlate with RMR. We conclude 1) T 3 did not influence intrinsic mitochondrial properties such as membrane structure and composition, and 2) variations in UCP-2 and -3 expression may partly explain variations in RMR. One possible explanation for these data is that T 3 stimulates the leak in vivo but not in vitro because a posttranslational regulator of UCP-2 and -3 is not retained in the mitochondrial fraction." @default.
• W2283656568 created "2016-06-24" @default.
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• W2283656568 date "1999-08-01" @default.
• W2283656568 modified "2023-10-17" @default.
• W2283656568 title "T₃stimulates resting metabolism and UCP-2 and UCP-3 mRNA but not nonphosphorylating mitochondrial respiration in mice" @default.
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• W2283656568 doi "https://doi.org/10.1152/ajpendo.1999.277.2.e380" @default.
• W2283656568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10444435" @default.
• W2283656568 hasPublicationYear "1999" @default.
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