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• W2283700 abstract "Since the classic study of Furchgott and Zawadzki [1] demonstrating the need of an intact endothelial cell layer for agents such as acetylcholine to have a relaxing effect on the blood vessel, an exploding body of literature has implicated the vascular endothelium as a source of relaxing factors. An important endothelial-derived relaxing factor (EDRF) is nitric oxide (NO), a short-lived gas molecule. NO is a highly reactive radical made from the amino acid L-arginine by the action of the enzyme nitric oxide synthase (NOS), releasing citrulline and NO [2]. A number of cofactors are required for this enzymatic reaction, as well as the availability of molecular oxygen. NO is formed throughout all vascular beds, and its basal release from endothelial cells may maintain normal blood vessel tone [3]. NO is also made by many different cell types in addition to endothelial cells, such as neutrophils, platelets, macrophages, and smooth muscle cells (SMC), as well as neurons [4,5]. In fact, there is increasing evidence that NO may function as a neurotransmitter in the brain to mediate the glutamate receptor signal transduction, and as an inhibitory, non-adrenergic, non-cholinergic neurotransmitter in the gastrointestinal and genito-urinary tracts [6]. Inflammatory cells and SMC express NO only in response to activation by endotoxin, interleukin(IL)-l, tumor necrosis factor (TNF), or interferon. This multifaceted molecule can therefore regulate a number of different processes, from inflammation, to neuronal signal transduction, to regulation of vascular tone.KeywordsNitric OxidePulmonary HypertensionAcute Lung InjuryPulmonary Arterial PressurePulmonary Arterial PressureThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
• W2283700 created "2016-06-24" @default.
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• W2283700 date "1998-01-01" @default.
• W2283700 modified "2023-09-27" @default.
• W2283700 title "Inhaled Nitric Oxide: Clinical Experience" @default.
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• W2283700 doi "https://doi.org/10.1007/978-3-642-60733-2_24" @default.
• W2283700 hasPublicationYear "1998" @default.
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