Matches in SemOpenAlex for { <https://semopenalex.org/work/W2283828165> ?p ?o ?g. }
- W2283828165 endingPage "1097" @default.
- W2283828165 startingPage "1089" @default.
- W2283828165 abstract "Fungal infections develop in pulmonary chronic inflammatory diseases such as asthma, Chronic Obstructive Pulmonary Disease (COPD) and Cystic Fibrosis (CF). The available antifungal drugs may fail to eradicate fungal pathogens, that can invade the lungs and vessels and spread by systemic circulation taking advantage of defective lung immunity. An increased rate of sphingolipid de novo synthesis, leading to ceramide accumulation, was demonstrated in CF and COPD inflamed lungs. The inhibitor of sphingolipid synthesis myriocin reduces inflammation and ameliorates the response against bacterial airway infection in CF mice. Myriocin also inhibits sphingolipid synthesis in fungi and exerts a powerful fungistatic effect. We treated Aspergillus fumigatus infected airway epithelial cells with myriocin and we administered myriocin-loaded nanocarriers to A. fumigatus infected mice lung. We demonstrate here that de novo synthesized ceramide mediates the inflammatory response induced by A. fumigatus infection in airway epithelia. CF epithelial cells are chronically inflamed and defective in killing internalized conidia. Myriocin treatment reduced ceramide increase and inflammatory mediator release whereas it upregulated HO1 and NOD2, allowing the recovery of a functional killing of conidia in these cells. Myriocin-loaded nanocarriers, intratracheally administered to mice, significantly reduced both the inflammatory response induced by A. fumigatus pulmonary challenge and fungal lung invasion. We conclude that inhibition of sphingolipid synthesis can be envisaged as a dual anti-inflammatory and anti-fungal therapy in patients suffering from chronic lung inflammation with compromised immunity. Myriocin represents a powerful agent for inflammatory diseases and fungal infection." @default.
- W2283828165 created "2016-06-24" @default.
- W2283828165 creator A5001356419 @default.
- W2283828165 creator A5005347599 @default.
- W2283828165 creator A5020738386 @default.
- W2283828165 creator A5026516846 @default.
- W2283828165 creator A5029702928 @default.
- W2283828165 creator A5038880665 @default.
- W2283828165 creator A5039191660 @default.
- W2283828165 creator A5048252980 @default.
- W2283828165 creator A5052585443 @default.
- W2283828165 creator A5084427308 @default.
- W2283828165 creator A5085425317 @default.
- W2283828165 date "2016-06-01" @default.
- W2283828165 modified "2023-10-01" @default.
- W2283828165 title "Inhibition of ceramide de novo synthesis by myriocin produces the double effect of reducing pathological inflammation and exerting antifungal activity against A. fumigatus airways infection" @default.
- W2283828165 cites W1748476074 @default.
- W2283828165 cites W1825544336 @default.
- W2283828165 cites W1897272853 @default.
- W2283828165 cites W1967716147 @default.
- W2283828165 cites W1970911936 @default.
- W2283828165 cites W1984143681 @default.
- W2283828165 cites W1986724254 @default.
- W2283828165 cites W1995061985 @default.
- W2283828165 cites W2001461508 @default.
- W2283828165 cites W2003561257 @default.
- W2283828165 cites W2007037118 @default.
- W2283828165 cites W2010539762 @default.
- W2283828165 cites W2028478901 @default.
- W2283828165 cites W2037266934 @default.
- W2283828165 cites W2042811693 @default.
- W2283828165 cites W2044923854 @default.
- W2283828165 cites W2049914201 @default.
- W2283828165 cites W2054302099 @default.
- W2283828165 cites W2068679706 @default.
- W2283828165 cites W2074120373 @default.
- W2283828165 cites W2074846423 @default.
- W2283828165 cites W2077266604 @default.
- W2283828165 cites W2077553424 @default.
- W2283828165 cites W2080818154 @default.
- W2283828165 cites W2082103066 @default.
- W2283828165 cites W2083850524 @default.
- W2283828165 cites W2099244520 @default.
- W2283828165 cites W2104432988 @default.
- W2283828165 cites W2104629765 @default.
- W2283828165 cites W2106244437 @default.
- W2283828165 cites W2108062829 @default.
- W2283828165 cites W2114552376 @default.
- W2283828165 cites W2114654732 @default.
- W2283828165 cites W2115206345 @default.
- W2283828165 cites W2121838954 @default.
- W2283828165 cites W212361883 @default.
- W2283828165 cites W2132114733 @default.
- W2283828165 cites W2132391778 @default.
- W2283828165 cites W2137149853 @default.
- W2283828165 cites W2139548208 @default.
- W2283828165 cites W2149340180 @default.
- W2283828165 cites W2151273305 @default.
- W2283828165 cites W2155025594 @default.
- W2283828165 cites W2164806733 @default.
- W2283828165 cites W2170620850 @default.
- W2283828165 cites W2300552860 @default.
- W2283828165 cites W2315376518 @default.
- W2283828165 cites W2328639121 @default.
- W2283828165 cites W2400570824 @default.
- W2283828165 doi "https://doi.org/10.1016/j.bbagen.2016.02.014" @default.
- W2283828165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26922830" @default.
- W2283828165 hasPublicationYear "2016" @default.
- W2283828165 type Work @default.
- W2283828165 sameAs 2283828165 @default.
- W2283828165 citedByCount "30" @default.
- W2283828165 countsByYear W22838281652016 @default.
- W2283828165 countsByYear W22838281652017 @default.
- W2283828165 countsByYear W22838281652018 @default.
- W2283828165 countsByYear W22838281652019 @default.
- W2283828165 countsByYear W22838281652020 @default.
- W2283828165 countsByYear W22838281652021 @default.
- W2283828165 countsByYear W22838281652022 @default.
- W2283828165 countsByYear W22838281652023 @default.
- W2283828165 crossrefType "journal-article" @default.
- W2283828165 hasAuthorship W2283828165A5001356419 @default.
- W2283828165 hasAuthorship W2283828165A5005347599 @default.
- W2283828165 hasAuthorship W2283828165A5020738386 @default.
- W2283828165 hasAuthorship W2283828165A5026516846 @default.
- W2283828165 hasAuthorship W2283828165A5029702928 @default.
- W2283828165 hasAuthorship W2283828165A5038880665 @default.
- W2283828165 hasAuthorship W2283828165A5039191660 @default.
- W2283828165 hasAuthorship W2283828165A5048252980 @default.
- W2283828165 hasAuthorship W2283828165A5052585443 @default.
- W2283828165 hasAuthorship W2283828165A5084427308 @default.
- W2283828165 hasAuthorship W2283828165A5085425317 @default.
- W2283828165 hasConcept C190283241 @default.
- W2283828165 hasConcept C203014093 @default.
- W2283828165 hasConcept C2776914184 @default.
- W2283828165 hasConcept C2777851122 @default.
- W2283828165 hasConcept C2779787849 @default.
- W2283828165 hasConcept C55493867 @default.
- W2283828165 hasConcept C61705674 @default.