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- W2283843731 abstract "To identify by molecular biology the alleles of alpha-Thal in selected hospital populations.Eighteen propositi with hematological and biochemical data suggestive of alpha-thalassemia, selected from 356 patients of four hospitals in two cities with probable hemoglobinopathy were investigated for six common alpha-Thal alleles. Molecular studies were done by PCR and digestion with specific restriction enzymes.The alpha 3.7 allele was identified in two cases and the family study revealed the same allele in the mother; HbS heterozigocity was also detected in one of them. An analysis with Apa I demonstrated a class I deletion in both patients. The present study showed 2/356 (0.6%) of alpha 3.71 carriers which is a low frequency as compared with other countries. As no other common alpha-thalassemia alleles were found, we suspect that alpha-Thal in Mexico is as heterogeneous at a molecular level as beta-Thal." @default.
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- W2283843731 date "1999-02-09" @default.
- W2283843731 modified "2023-09-26" @default.
- W2283843731 title "Alpha-thalassemia in a selected population of Mexico." @default.
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