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- W2283882020 abstract "Aim: To investigate if idiopathic Parkinson's disease (IPD) is associated with distinct proteolytic signatures relative to non-neurodegenerative controls (NND) and patients with multiple system atrophy (MSA). Materials & methods: A subtiligase-based N-terminomics screening method was exploited for semiquantitative comparison of protein N-termini in cerebrospinal fluid for pooled samples of IPD (n = 6) and NND (n = 8) individuals. Subsequently, targeted selected reaction monitoring mass spectrometry measured the relative concentration of the proteolytic signature peptides in individual IPD (n = 22), NND (n = 11) and MSA (n = 18) samples. Results: The discovery screen detected 300 N-termini for 156 proteins. Selected reaction monitoring analysis revealed that two of these peptides differentiate IPD from NND while three peptides differentiate IPD from MSA. Conclusion: IPD is associated with distinct proteolytic signatures." @default.
- W2283882020 created "2016-06-24" @default.
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- W2283882020 date "2016-02-01" @default.
- W2283882020 modified "2023-10-16" @default.
- W2283882020 title "Detection of proteolytic signatures for Parkinson's disease" @default.
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- W2283882020 doi "https://doi.org/10.2217/fnl.16.3" @default.
- W2283882020 hasPublicationYear "2016" @default.
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