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- W2283894503 abstract "Significance Somatosensory information is transmitted and processed in the superficial layer (layer 2/3) of the cortex, giving rise to proper sensory perception. These processes ought to be dependent on the patterns of neuronal connectivity among layer 2/3 neurons, but underlying cellular mechanisms that govern how one neuron makes specific connections with other neurons and eventually builds functional microcircuits are not fully understood. We found that spikes generated in multiple neurons in vivo induced the formation of a functional group of neurons. Further data demonstrated that functional connectivity was determined by the order of the spike sequence and the number of neurons but not by the physical distance among neurons. These results imply that time-sensitive neuronal activity determines the pattern of circuit connectivity." @default.
- W2283894503 created "2016-06-24" @default.
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- W2283894503 date "2016-02-22" @default.
- W2283894503 modified "2023-10-15" @default.
- W2283894503 title "Emergence of functional subnetworks in layer 2/3 cortex induced by sequential spikes in vivo" @default.
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- W2283894503 doi "https://doi.org/10.1073/pnas.1513410113" @default.
- W2283894503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4791016" @default.
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