Matches in SemOpenAlex for { <https://semopenalex.org/work/W2284024826> ?p ?o ?g. }
- W2284024826 abstract "Introduction: Tobacco dependence is a chronic disorder that carries the risk of relapse at any time point during abstinence. It is a major health issue in the world and current pharmacotherapies have had limited efficacy. Therefore, development and validation of novel treatments are required.Objective: Investigate the novel neutral cannabinoid-1 receptor antagonist AM4113 on nicotine (main psychoactive ingredient in tobacco)-taking behaviour in animals. Methods: Using the nicotine intravenous- and food control- self administration paradigms, we tested the acute and chronic (10-days) effects of AM4113 on nicotine- and food-taking behaviour.Results: Acute AM4113 treatments (1-, 3-, 10-mg/kg) reduced nicotine self administration. Chronic AM4113 administration (10mg/kg) produced a sustained reduction of nicotine-taking behaviour during the course of the treatment. In the similar food control self administration experiments, AM4113 overall produced no effect. Conclusion: AM4113 can attenuate nicotine-taking behaviour and its effect is sustained under chronic treatment.%%%%MAST" @default.
- W2284024826 created "2016-06-24" @default.
- W2284024826 creator A5030938762 @default.
- W2284024826 date "2014-03-19" @default.
- W2284024826 modified "2023-09-27" @default.
- W2284024826 title "The Effects of a Neutral Cannabinoid-1 Receptor Antagonist on Intravenous Nicotine Self Administration Behaviour" @default.
- W2284024826 cites W1533897695 @default.
- W2284024826 cites W1539232610 @default.
- W2284024826 cites W1540199296 @default.
- W2284024826 cites W1553897055 @default.
- W2284024826 cites W155846689 @default.
- W2284024826 cites W1654380405 @default.
- W2284024826 cites W1884398615 @default.
- W2284024826 cites W1972857557 @default.
- W2284024826 cites W1974215173 @default.
- W2284024826 cites W1974444071 @default.
- W2284024826 cites W1975640654 @default.
- W2284024826 cites W1994180387 @default.
- W2284024826 cites W1997189506 @default.
- W2284024826 cites W2011154525 @default.
- W2284024826 cites W2015109725 @default.
- W2284024826 cites W2015594800 @default.
- W2284024826 cites W2018003279 @default.
- W2284024826 cites W2019530923 @default.
- W2284024826 cites W2021143648 @default.
- W2284024826 cites W2022107440 @default.
- W2284024826 cites W2025440394 @default.
- W2284024826 cites W2025543167 @default.
- W2284024826 cites W2027150013 @default.
- W2284024826 cites W2040077055 @default.
- W2284024826 cites W2040527156 @default.
- W2284024826 cites W2049324875 @default.
- W2284024826 cites W2049876674 @default.
- W2284024826 cites W2051741667 @default.
- W2284024826 cites W2054098661 @default.
- W2284024826 cites W2055158862 @default.
- W2284024826 cites W2056710937 @default.
- W2284024826 cites W2061265320 @default.
- W2284024826 cites W2070212982 @default.
- W2284024826 cites W2073239622 @default.
- W2284024826 cites W2078241277 @default.
- W2284024826 cites W2080649553 @default.
- W2284024826 cites W2081934997 @default.
- W2284024826 cites W2085860270 @default.
- W2284024826 cites W2086781281 @default.
- W2284024826 cites W2087354578 @default.
- W2284024826 cites W2095688984 @default.
- W2284024826 cites W2098660078 @default.
- W2284024826 cites W2099617879 @default.
- W2284024826 cites W2104645663 @default.
- W2284024826 cites W2105124652 @default.
- W2284024826 cites W2109784228 @default.
- W2284024826 cites W2116268998 @default.
- W2284024826 cites W2119735577 @default.
- W2284024826 cites W2131366415 @default.
- W2284024826 cites W2148758048 @default.
- W2284024826 cites W2150821313 @default.
- W2284024826 cites W2157977435 @default.
- W2284024826 cites W2158696674 @default.
- W2284024826 cites W2158987544 @default.
- W2284024826 cites W2416098844 @default.
- W2284024826 hasPublicationYear "2014" @default.
- W2284024826 type Work @default.
- W2284024826 sameAs 2284024826 @default.
- W2284024826 citedByCount "0" @default.
- W2284024826 crossrefType "dissertation" @default.
- W2284024826 hasAuthorship W2284024826A5030938762 @default.
- W2284024826 hasConcept C118552586 @default.
- W2284024826 hasConcept C126322002 @default.
- W2284024826 hasConcept C170493617 @default.
- W2284024826 hasConcept C2776885963 @default.
- W2284024826 hasConcept C2778555786 @default.
- W2284024826 hasConcept C2779547902 @default.
- W2284024826 hasConcept C2780687700 @default.
- W2284024826 hasConcept C2780871563 @default.
- W2284024826 hasConcept C71924100 @default.
- W2284024826 hasConcept C98274493 @default.
- W2284024826 hasConceptScore W2284024826C118552586 @default.
- W2284024826 hasConceptScore W2284024826C126322002 @default.
- W2284024826 hasConceptScore W2284024826C170493617 @default.
- W2284024826 hasConceptScore W2284024826C2776885963 @default.
- W2284024826 hasConceptScore W2284024826C2778555786 @default.
- W2284024826 hasConceptScore W2284024826C2779547902 @default.
- W2284024826 hasConceptScore W2284024826C2780687700 @default.
- W2284024826 hasConceptScore W2284024826C2780871563 @default.
- W2284024826 hasConceptScore W2284024826C71924100 @default.
- W2284024826 hasConceptScore W2284024826C98274493 @default.
- W2284024826 hasLocation W22840248261 @default.
- W2284024826 hasOpenAccess W2284024826 @default.
- W2284024826 hasPrimaryLocation W22840248261 @default.
- W2284024826 hasRelatedWork W1884398615 @default.
- W2284024826 hasRelatedWork W1965739631 @default.
- W2284024826 hasRelatedWork W1966466179 @default.
- W2284024826 hasRelatedWork W1996302313 @default.
- W2284024826 hasRelatedWork W2021143648 @default.
- W2284024826 hasRelatedWork W2021292659 @default.
- W2284024826 hasRelatedWork W2042090342 @default.
- W2284024826 hasRelatedWork W2043500319 @default.
- W2284024826 hasRelatedWork W2070212982 @default.
- W2284024826 hasRelatedWork W2072319650 @default.