Matches in SemOpenAlex for { <https://semopenalex.org/work/W2284027774> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2284027774 abstract "Hyperaldosteronsim is associated with increased pulmonary vascular remodeling in patients with pulmonary arterial hypertension (PAH). In cardiomyocytes, aldosterone (ALDO) promotes collagen deposition by increasing levels of connective tissue growth factor (CTGF). The role of CTGF in ALDO-mediated vascular remodeling in PAH, however, is not known. We hypothesized that upregulation of CTGF by ALDO is a novel signaling mechanism that modulates pulmonary vascular fibrosis in PAH. To test this hypothesis, cultured human pulmonary artery endothelial cells were exposed to ALDO (10 -9 -10 -7 mol/l) for 24 hr and changes in CTGF levels were assessed by immunoblotting. Compared to vehicle control, ALDO induced a dose-dependent increase in CTGF expression (3.4 ± 0.2 vs. 6.7 ± 1.9 vs. 10.4 ± 1.6 vs. 17.6 ± 1.9 units, P=0.02). We next investigated the effect of ALDO on CTGF in PAH in vivo. Compared to controls, rats exposed to SU-5416 (20 mg/kg) and hypoxia (10% O 2 ) (Su/Hyp) for 21 d demonstrated increased pulmonary artery systolic pressure (PASP) (26 ± 2 vs. 81 ± 5 mmHg, P" @default.
- W2284027774 created "2016-06-24" @default.
- W2284027774 creator A5028396638 @default.
- W2284027774 creator A5031499770 @default.
- W2284027774 creator A5045540814 @default.
- W2284027774 creator A5061025856 @default.
- W2284027774 creator A5083877700 @default.
- W2284027774 date "2013-11-26" @default.
- W2284027774 modified "2023-09-26" @default.
- W2284027774 title "Abstract 9809: Upregulation of Aldosterone by Steroidogenesis Acute Regulatory Protein (StAR) is Associated With Connective Tissue Growth Factor-Mediated Pulmonary Vascular Fibrosis in Pulmonary Arterial Hypertension In Vivo" @default.
- W2284027774 hasPublicationYear "2013" @default.
- W2284027774 type Work @default.
- W2284027774 sameAs 2284027774 @default.
- W2284027774 citedByCount "0" @default.
- W2284027774 crossrefType "journal-article" @default.
- W2284027774 hasAuthorship W2284027774A5028396638 @default.
- W2284027774 hasAuthorship W2284027774A5031499770 @default.
- W2284027774 hasAuthorship W2284027774A5045540814 @default.
- W2284027774 hasAuthorship W2284027774A5061025856 @default.
- W2284027774 hasAuthorship W2284027774A5083877700 @default.
- W2284027774 hasConcept C104317684 @default.
- W2284027774 hasConcept C126322002 @default.
- W2284027774 hasConcept C127561419 @default.
- W2284027774 hasConcept C134018914 @default.
- W2284027774 hasConcept C142724271 @default.
- W2284027774 hasConcept C150903083 @default.
- W2284027774 hasConcept C167734588 @default.
- W2284027774 hasConcept C170493617 @default.
- W2284027774 hasConcept C178790620 @default.
- W2284027774 hasConcept C185592680 @default.
- W2284027774 hasConcept C207001950 @default.
- W2284027774 hasConcept C2775960820 @default.
- W2284027774 hasConcept C2777025900 @default.
- W2284027774 hasConcept C2778525890 @default.
- W2284027774 hasConcept C2780559512 @default.
- W2284027774 hasConcept C2780631158 @default.
- W2284027774 hasConcept C2780930700 @default.
- W2284027774 hasConcept C2780940725 @default.
- W2284027774 hasConcept C2781244666 @default.
- W2284027774 hasConcept C518705261 @default.
- W2284027774 hasConcept C540031477 @default.
- W2284027774 hasConcept C55493867 @default.
- W2284027774 hasConcept C71924100 @default.
- W2284027774 hasConcept C7836513 @default.
- W2284027774 hasConcept C86803240 @default.
- W2284027774 hasConceptScore W2284027774C104317684 @default.
- W2284027774 hasConceptScore W2284027774C126322002 @default.
- W2284027774 hasConceptScore W2284027774C127561419 @default.
- W2284027774 hasConceptScore W2284027774C134018914 @default.
- W2284027774 hasConceptScore W2284027774C142724271 @default.
- W2284027774 hasConceptScore W2284027774C150903083 @default.
- W2284027774 hasConceptScore W2284027774C167734588 @default.
- W2284027774 hasConceptScore W2284027774C170493617 @default.
- W2284027774 hasConceptScore W2284027774C178790620 @default.
- W2284027774 hasConceptScore W2284027774C185592680 @default.
- W2284027774 hasConceptScore W2284027774C207001950 @default.
- W2284027774 hasConceptScore W2284027774C2775960820 @default.
- W2284027774 hasConceptScore W2284027774C2777025900 @default.
- W2284027774 hasConceptScore W2284027774C2778525890 @default.
- W2284027774 hasConceptScore W2284027774C2780559512 @default.
- W2284027774 hasConceptScore W2284027774C2780631158 @default.
- W2284027774 hasConceptScore W2284027774C2780930700 @default.
- W2284027774 hasConceptScore W2284027774C2780940725 @default.
- W2284027774 hasConceptScore W2284027774C2781244666 @default.
- W2284027774 hasConceptScore W2284027774C518705261 @default.
- W2284027774 hasConceptScore W2284027774C540031477 @default.
- W2284027774 hasConceptScore W2284027774C55493867 @default.
- W2284027774 hasConceptScore W2284027774C71924100 @default.
- W2284027774 hasConceptScore W2284027774C7836513 @default.
- W2284027774 hasConceptScore W2284027774C86803240 @default.
- W2284027774 hasLocation W22840277741 @default.
- W2284027774 hasOpenAccess W2284027774 @default.
- W2284027774 hasPrimaryLocation W22840277741 @default.
- W2284027774 hasRelatedWork W1820008561 @default.
- W2284027774 hasRelatedWork W2021201151 @default.
- W2284027774 hasRelatedWork W2046087773 @default.
- W2284027774 hasRelatedWork W2148840917 @default.
- W2284027774 hasRelatedWork W2161386765 @default.
- W2284027774 hasRelatedWork W2167319946 @default.
- W2284027774 hasRelatedWork W2314837355 @default.
- W2284027774 hasRelatedWork W2467471120 @default.
- W2284027774 hasRelatedWork W2500440317 @default.
- W2284027774 hasRelatedWork W2793051655 @default.
- W2284027774 hasRelatedWork W2798018724 @default.
- W2284027774 hasRelatedWork W2883785913 @default.
- W2284027774 hasRelatedWork W2884485693 @default.
- W2284027774 hasRelatedWork W2911459230 @default.
- W2284027774 hasRelatedWork W2916030096 @default.
- W2284027774 hasRelatedWork W2975718866 @default.
- W2284027774 hasRelatedWork W2990197046 @default.
- W2284027774 hasRelatedWork W3001317215 @default.
- W2284027774 hasRelatedWork W3013571670 @default.
- W2284027774 hasRelatedWork W3120671134 @default.
- W2284027774 hasVolume "128" @default.
- W2284027774 isParatext "false" @default.
- W2284027774 isRetracted "false" @default.
- W2284027774 magId "2284027774" @default.
- W2284027774 workType "article" @default.