Matches in SemOpenAlex for { <https://semopenalex.org/work/W2284061716> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2284061716 endingPage "31" @default.
- W2284061716 startingPage "1023" @default.
- W2284061716 abstract "2-Amino-N-(1,2-diphenylethyl)-acetamide-hydrochloride (FPL 13950) was profiled preclinically in rodents for efficacy against convulsions, as well as for acute safety/behavioral observations. FPL 13950 exhibited good oral efficacy and duration of action with respect to prevention of seizures elicited by maximal electroshock-shock in both rats and mice. Tolerance to protection against maximal electroshock and hexobarbital-induced sleep-time was not evident after subchronic drug administration. FPL 13950 also prevented convulsions/mortality in mice after i.v. dosing with N-methyl-D, L-aspartate, however, it was ineffective against other types of chemically induced convulsions, as well as bicorneal kindling. High oral doses produced neural impairment in both mice and rats and hyperactivity in rats. Sequential administration of yet higher doses elicited tonic/clonic convulsions culminating in death. During i.v. infusion of metrazol in mice, high i.p. doses of FPL 13950 shortened the latency to first twitch and clonus. No increase in the startle response or phencyclidine-like behavior was evident after oral dosing in rats." @default.
- W2284061716 created "2016-06-24" @default.
- W2284061716 creator A5008446035 @default.
- W2284061716 creator A5018288672 @default.
- W2284061716 creator A5033804334 @default.
- W2284061716 creator A5035955440 @default.
- W2284061716 creator A5040410472 @default.
- W2284061716 creator A5041105444 @default.
- W2284061716 creator A5053681737 @default.
- W2284061716 creator A5062498742 @default.
- W2284061716 creator A5065008045 @default.
- W2284061716 creator A5088706930 @default.
- W2284061716 date "1995-06-01" @default.
- W2284061716 modified "2023-09-27" @default.
- W2284061716 title "Anticonvulsant efficacy/safety properties of 2-amino-N-(1,2-diphenylethyl)acetamide hydrochloride." @default.
- W2284061716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7791072" @default.
- W2284061716 hasPublicationYear "1995" @default.
- W2284061716 type Work @default.
- W2284061716 sameAs 2284061716 @default.
- W2284061716 citedByCount "1" @default.
- W2284061716 crossrefType "journal-article" @default.
- W2284061716 hasAuthorship W2284061716A5008446035 @default.
- W2284061716 hasAuthorship W2284061716A5018288672 @default.
- W2284061716 hasAuthorship W2284061716A5033804334 @default.
- W2284061716 hasAuthorship W2284061716A5035955440 @default.
- W2284061716 hasAuthorship W2284061716A5040410472 @default.
- W2284061716 hasAuthorship W2284061716A5041105444 @default.
- W2284061716 hasAuthorship W2284061716A5053681737 @default.
- W2284061716 hasAuthorship W2284061716A5062498742 @default.
- W2284061716 hasAuthorship W2284061716A5065008045 @default.
- W2284061716 hasAuthorship W2284061716A5088706930 @default.
- W2284061716 hasConcept C118552586 @default.
- W2284061716 hasConcept C181199279 @default.
- W2284061716 hasConcept C185592680 @default.
- W2284061716 hasConcept C2775858608 @default.
- W2284061716 hasConcept C2777010014 @default.
- W2284061716 hasConcept C2777288759 @default.
- W2284061716 hasConcept C2777466164 @default.
- W2284061716 hasConcept C2778186239 @default.
- W2284061716 hasConcept C2779994606 @default.
- W2284061716 hasConcept C42219234 @default.
- W2284061716 hasConcept C55493867 @default.
- W2284061716 hasConcept C71924100 @default.
- W2284061716 hasConcept C87644729 @default.
- W2284061716 hasConcept C98274493 @default.
- W2284061716 hasConceptScore W2284061716C118552586 @default.
- W2284061716 hasConceptScore W2284061716C181199279 @default.
- W2284061716 hasConceptScore W2284061716C185592680 @default.
- W2284061716 hasConceptScore W2284061716C2775858608 @default.
- W2284061716 hasConceptScore W2284061716C2777010014 @default.
- W2284061716 hasConceptScore W2284061716C2777288759 @default.
- W2284061716 hasConceptScore W2284061716C2777466164 @default.
- W2284061716 hasConceptScore W2284061716C2778186239 @default.
- W2284061716 hasConceptScore W2284061716C2779994606 @default.
- W2284061716 hasConceptScore W2284061716C42219234 @default.
- W2284061716 hasConceptScore W2284061716C55493867 @default.
- W2284061716 hasConceptScore W2284061716C71924100 @default.
- W2284061716 hasConceptScore W2284061716C87644729 @default.
- W2284061716 hasConceptScore W2284061716C98274493 @default.
- W2284061716 hasIssue "3" @default.
- W2284061716 hasLocation W22840617161 @default.
- W2284061716 hasOpenAccess W2284061716 @default.
- W2284061716 hasPrimaryLocation W22840617161 @default.
- W2284061716 hasRelatedWork W133690204 @default.
- W2284061716 hasRelatedWork W1977753240 @default.
- W2284061716 hasRelatedWork W2023281672 @default.
- W2284061716 hasRelatedWork W2041083297 @default.
- W2284061716 hasRelatedWork W2067686370 @default.
- W2284061716 hasRelatedWork W2076869135 @default.
- W2284061716 hasRelatedWork W2181977173 @default.
- W2284061716 hasRelatedWork W2265641243 @default.
- W2284061716 hasRelatedWork W2407730090 @default.
- W2284061716 hasRelatedWork W2395712876 @default.
- W2284061716 hasVolume "273" @default.
- W2284061716 isParatext "false" @default.
- W2284061716 isRetracted "false" @default.
- W2284061716 magId "2284061716" @default.
- W2284061716 workType "article" @default.