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- W2284076444 abstract "The measurement that is termed 'LDL-cholesterol' (LDL-C) includes the cholesterol content of lipoprotein(a) [Lp(a)-C], which can contribute approximately 30-45% to measured LDL-C levels as a percentage of its mass. We review the implications of achieved very low LDL-C levels in patients treated with potent LDL-C-lowering agents in the context of varying Lp(a) levels.Combination therapy with statins, ezetimibe, and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors can lower LDL-C to unprecedentedly low levels. Recent PCSK9 trials have shown that routine achievement of mean LDL-C less than 50 mg/dl is feasible, along with the modest reductions in Lp(a). Many patients will achieve LDL-C less than 25 mg/dl with concomitantly elevated Lp(a) levels that contribute substantially to the measured 'LDL-C'. Therefore, it is possible that some of these patients may have little to no circulating LDL-C.As the new era of ultralow LDL-C levels ensues, it is imperative to understand the contribution of Lp(a)-C to measured LDL-C and the consequences of achieving ultralow or potentially absent LDL-C in the setting of elevated Lp(a) levels and possibly free apo(a). We review this concept and suggest avenues of research, including analyses of existing datasets in current clinical trials and new research studies, to understand its pathophysiological and clinical significance." @default.
- W2284076444 created "2016-06-24" @default.
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- W2284076444 date "2015-06-01" @default.
- W2284076444 modified "2023-10-18" @default.
- W2284076444 title "‘LDL-C’ = LDL-C + Lp(a)-C" @default.
- W2284076444 cites W121888607 @default.
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- W2284076444 cites W161816689 @default.
- W2284076444 cites W1643136010 @default.
- W2284076444 cites W1915791432 @default.
- W2284076444 cites W1923289550 @default.
- W2284076444 cites W1955722982 @default.
- W2284076444 cites W1981043019 @default.
- W2284076444 cites W1989100969 @default.
- W2284076444 cites W1990204315 @default.
- W2284076444 cites W1994699782 @default.
- W2284076444 cites W2012067432 @default.
- W2284076444 cites W2013493542 @default.
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- W2284076444 cites W2018010993 @default.
- W2284076444 cites W2040247371 @default.
- W2284076444 cites W2040612932 @default.
- W2284076444 cites W2045624939 @default.
- W2284076444 cites W2050228630 @default.
- W2284076444 cites W2053513183 @default.
- W2284076444 cites W2054299101 @default.
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- W2284076444 doi "https://doi.org/10.1097/mol.0000000000000171" @default.
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