FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2284080609> ?p ?o ?g. }

• W2284080609 endingPage "1568" @default.
• W2284080609 startingPage "1555" @default.
• W2284080609 abstract "Patients with type 2 diabetes (T2D) are at increased risk for cardiovascular diseases including diabetic cardiomyopathy, which is ventricular dysfunction independent of underlying coronary artery disease and/or hypertension. With numerous advancements in our ability to detect ventricular dysfunction, as well as the molecular mechanisms contributing to ventricular dysfunction in diabetic patients, it is now appreciated that diabetic cardiomyopathy is becoming more prevalent in our population. In spite of these advancements, we do not have any specific therapies currently approved for treating this condition. As obesity increases the risk for both T2D and cardiovascular disease, it has been postulated that obesity-mediated alterations in myocardial lipid metabolism are critical to the pathophysiology of diabetic cardiomyopathy. Indeed, animal studies have provided strong evidence that alterations in either myocardial fatty acid uptake or fatty acid β-oxidation lead to the accumulation of various lipid intermediates including triacylglycerol, diacylglycerol, ceramide, long-chain acyl CoA, acylcarnitine, and many others that are tightly linked to the progression of ventricular dysfunction. We review herein why lipid intermediates accumulate in the heart during obesity and/or T2D, with a focus on which of these various lipid intermediates may be responsible for cardiac lipotoxicity, and whether findings in animal models are relevant to humans. An improved understanding of how these lipid intermediates accumulate in the heart and how they produce cardiac toxicity may lead to the discovery of novel targets to pursue for the treatment of human diabetic cardiomyopathy. This article is part of a Special Issue entitled: Heart Lipid Metabolism edited by G.D. Lopaschuk." @default.
• W2284080609 created "2016-06-24" @default.
• W2284080609 creator A5024507895 @default.
• W2284080609 creator A5070222377 @default.
• W2284080609 creator A5083733494 @default.
• W2284080609 date "2016-10-01" @default.
• W2284080609 modified "2023-10-04" @default.
• W2284080609 title "Lipotoxicity in obesity and diabetes-related cardiac dysfunction" @default.
• W2284080609 cites W1491296468 @default.
• W2284080609 cites W1495212988 @default.
• W2284080609 cites W1519485868 @default.
• W2284080609 cites W156869561 @default.
• W2284080609 cites W1601097124 @default.
• W2284080609 cites W1800414896 @default.
• W2284080609 cites W1844194650 @default.
• W2284080609 cites W1930548203 @default.
• W2284080609 cites W1953327177 @default.
• W2284080609 cites W1964681419 @default.
• W2284080609 cites W1965453788 @default.
• W2284080609 cites W1967400215 @default.
• W2284080609 cites W1968715224 @default.
• W2284080609 cites W1970653898 @default.
• W2284080609 cites W1975421091 @default.
• W2284080609 cites W1980821438 @default.
• W2284080609 cites W1983006621 @default.
• W2284080609 cites W1983050178 @default.
• W2284080609 cites W1984809600 @default.
• W2284080609 cites W1985592156 @default.
• W2284080609 cites W1987015387 @default.
• W2284080609 cites W1987320803 @default.
• W2284080609 cites W1987377847 @default.
• W2284080609 cites W1988183203 @default.
• W2284080609 cites W1989652805 @default.
• W2284080609 cites W1990675802 @default.
• W2284080609 cites W1993722516 @default.
• W2284080609 cites W1993956461 @default.
• W2284080609 cites W1997402472 @default.
• W2284080609 cites W1997737160 @default.
• W2284080609 cites W1999136265 @default.
• W2284080609 cites W2001252698 @default.
• W2284080609 cites W2001312856 @default.
• W2284080609 cites W2001466001 @default.
• W2284080609 cites W2002456170 @default.
• W2284080609 cites W2002711503 @default.
• W2284080609 cites W2007527212 @default.
• W2284080609 cites W2010433305 @default.
• W2284080609 cites W2010601216 @default.
• W2284080609 cites W2010819467 @default.
• W2284080609 cites W2010993941 @default.
• W2284080609 cites W2012898950 @default.
• W2284080609 cites W2013028549 @default.
• W2284080609 cites W2013454579 @default.
• W2284080609 cites W2014671368 @default.
• W2284080609 cites W2016728909 @default.
• W2284080609 cites W2019882926 @default.
• W2284080609 cites W2019999805 @default.
• W2284080609 cites W2025362447 @default.
• W2284080609 cites W2026199993 @default.
• W2284080609 cites W2027022541 @default.
• W2284080609 cites W2029318573 @default.
• W2284080609 cites W2030901818 @default.
• W2284080609 cites W2031449170 @default.
• W2284080609 cites W2031846075 @default.
• W2284080609 cites W2032264012 @default.
• W2284080609 cites W2038013958 @default.
• W2284080609 cites W2039348476 @default.
• W2284080609 cites W2040197119 @default.
• W2284080609 cites W2041886157 @default.
• W2284080609 cites W2042706232 @default.
• W2284080609 cites W2046658782 @default.
• W2284080609 cites W2047399305 @default.
• W2284080609 cites W2051278797 @default.
• W2284080609 cites W2051321232 @default.
• W2284080609 cites W2052177959 @default.
• W2284080609 cites W2053547821 @default.
• W2284080609 cites W2057816478 @default.
• W2284080609 cites W2058536977 @default.
• W2284080609 cites W2059458337 @default.
• W2284080609 cites W2061176979 @default.
• W2284080609 cites W2062757144 @default.
• W2284080609 cites W2065504943 @default.
• W2284080609 cites W2071518542 @default.
• W2284080609 cites W2073656642 @default.
• W2284080609 cites W2075111851 @default.
• W2284080609 cites W2075210458 @default.
• W2284080609 cites W2077261489 @default.
• W2284080609 cites W2079796426 @default.
• W2284080609 cites W2080217697 @default.
• W2284080609 cites W2083277239 @default.
• W2284080609 cites W2083910600 @default.
• W2284080609 cites W2087410169 @default.
• W2284080609 cites W2087503324 @default.
• W2284080609 cites W2088001693 @default.
• W2284080609 cites W2088136245 @default.
• W2284080609 cites W2089877066 @default.
• W2284080609 cites W2090946848 @default.
• W2284080609 cites W2093186342 @default.
• W2284080609 cites W2098822834 @default.

• next