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• W2284105857 abstract "In the recent study of investigation, the genotoxic effect of leaf extract of Phyllanthus niruri has been analysed against UV-induced chromosomal aberration in the bone marrow cells of mice. Single i.p. administration of Phyllanthus niruri leaf extract at three different doses namely 250, 500 and 750 mg/kg b. wt. have provided protection when given 24 hr prior to the exposure of Ultra Violet radiation (UV B, 315 nm). A dose inhibition of chromosomal aberration was observed which was statistically significant (p<0.05) as compared to the UV treated group. In another set of experiment, the antioxidant activity of Phyllanthus niruri leaf extract using Fenton reaction was also observed and we found a dose dependent inhibition of Thiobarbituric acid reactive substance (TBARS) as compared to positive control. The minimum inhibitory concentration 50% of P. niruri and DMSO was found to be 68.76 and 56.98 respectively. Its seems to have a preventive potential against UV induced chromosomal aberrations in the bone marrow cells of the mice and also found antioxidant activity. Therefore, the results suggest a genotoxic and antioxidant potential of Phyllanthus niruri leaf extract." @default.
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• W2284105857 date "2011-01-01" @default.
• W2284105857 modified "2023-09-23" @default.
• W2284105857 title "Effect of Phyllanthus niruri Leaf Extract on Antioxidant Activity and UV Induced Chromosomal Aberration in Swiss Albino Mice" @default.
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