FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2284151925> ?p ?o ?g. }

• W2284151925 endingPage "75" @default.
• W2284151925 startingPage "64" @default.
• W2284151925 abstract "Eph–ephrin interactions guide topographic mapping and pattern formation in a variety of systems. In contrast to other sensory pathways, their precise role in the assembly of central auditory circuits remains poorly understood. The auditory midbrain, or inferior colliculus (IC) is an intriguing structure for exploring guidance of patterned projections as adjacent subdivisions exhibit distinct organizational features. The central nucleus of the IC (CNIC) and deep aspects of its neighboring lateral cortex (LCIC, Layer 3) are tonotopically-organized and receive layered inputs from primarily downstream auditory sources. While less is known about more superficial aspects of the LCIC, its inputs are multimodal, lack a clear tonotopic order, and appear discontinuous, terminating in modular, patch/matrix-like distributions. Here we utilize X-Gal staining approaches in lacZ mutant mice (ephrin-B2, -B3, and EphA4) to reveal EphA–ephrinB expression patterns in the nascent IC during the period of projection shaping that precedes hearing onset. We also report early postnatal protein expression in the cochlear nuclei, the superior olivary complex, the nuclei of the lateral lemniscus, and relevant midline structures. Continuous ephrin-B2 and EphA4 expression gradients exist along frequency axes of the CNIC and LCIC Layer 3. In contrast, more superficial LCIC localization is not graded, but confined to a series of discrete ephrin-B2 and EphA4-positive Layer 2 modules. While heavily expressed in the midline, much of the auditory brainstem is devoid of ephrin-B3, including the CNIC, LCIC Layer 2 modular fields, the dorsal nucleus of the lateral lemniscus (DNLL), as well as much of the superior olivary complex and cochlear nuclei. Ephrin-B3 LCIC expression appears complementary to that of ephrin-B2 and EphA4, with protein most concentrated in presumptive extramodular zones. Described tonotopic gradients and seemingly complementary modular/extramodular patterns suggest Eph–ephrin guidance in establishing juxtaposed continuous and discrete neural maps in the developing IC prior to experience." @default.
• W2284151925 created "2016-06-24" @default.
• W2284151925 creator A5007346525 @default.
• W2284151925 creator A5017219333 @default.
• W2284151925 creator A5045470462 @default.
• W2284151925 creator A5071516359 @default.
• W2284151925 creator A5082207870 @default.
• W2284151925 date "2016-05-01" @default.
• W2284151925 modified "2023-10-12" @default.
• W2284151925 title "Graded and discontinuous EphA–ephrinB expression patterns in the developing auditory brainstem" @default.
• W2284151925 cites W1532998256 @default.
• W2284151925 cites W1949156715 @default.
• W2284151925 cites W1964360471 @default.
• W2284151925 cites W1973200223 @default.
• W2284151925 cites W1978105135 @default.
• W2284151925 cites W1978148843 @default.
• W2284151925 cites W1979052103 @default.
• W2284151925 cites W1985205712 @default.
• W2284151925 cites W1990483748 @default.
• W2284151925 cites W1992179025 @default.
• W2284151925 cites W1995261404 @default.
• W2284151925 cites W1997318952 @default.
• W2284151925 cites W1999883312 @default.
• W2284151925 cites W2001040684 @default.
• W2284151925 cites W2004276760 @default.
• W2284151925 cites W2008118471 @default.
• W2284151925 cites W2010964377 @default.
• W2284151925 cites W2015863739 @default.
• W2284151925 cites W2026186274 @default.
• W2284151925 cites W2033276252 @default.
• W2284151925 cites W2034885943 @default.
• W2284151925 cites W2035690763 @default.
• W2284151925 cites W2038894508 @default.
• W2284151925 cites W2051622265 @default.
• W2284151925 cites W2051734995 @default.
• W2284151925 cites W2059989239 @default.
• W2284151925 cites W2060789499 @default.
• W2284151925 cites W2063997169 @default.
• W2284151925 cites W2064963621 @default.
• W2284151925 cites W2065590047 @default.
• W2284151925 cites W2068286495 @default.
• W2284151925 cites W2072861396 @default.
• W2284151925 cites W2075832981 @default.
• W2284151925 cites W2076939471 @default.
• W2284151925 cites W2079346946 @default.
• W2284151925 cites W2081667702 @default.
• W2284151925 cites W2083158374 @default.
• W2284151925 cites W2089877473 @default.
• W2284151925 cites W2092845948 @default.
• W2284151925 cites W2096309094 @default.
• W2284151925 cites W2098216753 @default.
• W2284151925 cites W2098447426 @default.
• W2284151925 cites W2105107414 @default.
• W2284151925 cites W2106165942 @default.
• W2284151925 cites W2112457167 @default.
• W2284151925 cites W2116044769 @default.
• W2284151925 cites W2122946342 @default.
• W2284151925 cites W2138072363 @default.
• W2284151925 cites W2143076872 @default.
• W2284151925 cites W2147842326 @default.
• W2284151925 cites W2150448908 @default.
• W2284151925 cites W2155207257 @default.
• W2284151925 cites W2156570538 @default.
• W2284151925 cites W2158227053 @default.
• W2284151925 cites W2159736139 @default.
• W2284151925 cites W2170587329 @default.
• W2284151925 cites W2420783522 @default.
• W2284151925 cites W4211098371 @default.
• W2284151925 cites W4237569337 @default.
• W2284151925 cites W4239737188 @default.
• W2284151925 cites W4240565206 @default.
• W2284151925 cites W4243156630 @default.
• W2284151925 cites W4245104574 @default.
• W2284151925 cites W4246226533 @default.
• W2284151925 cites W4253686750 @default.
• W2284151925 cites W4255047149 @default.
• W2284151925 cites W4256388013 @default.
• W2284151925 doi "https://doi.org/10.1016/j.heares.2016.02.013" @default.
• W2284151925 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4860048" @default.
• W2284151925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26906676" @default.
• W2284151925 hasPublicationYear "2016" @default.
• W2284151925 type Work @default.
• W2284151925 sameAs 2284151925 @default.
• W2284151925 citedByCount "14" @default.
• W2284151925 countsByYear W22841519252017 @default.
• W2284151925 countsByYear W22841519252018 @default.
• W2284151925 countsByYear W22841519252019 @default.
• W2284151925 countsByYear W22841519252020 @default.
• W2284151925 countsByYear W22841519252021 @default.
• W2284151925 countsByYear W22841519252022 @default.
• W2284151925 countsByYear W22841519252023 @default.
• W2284151925 crossrefType "journal-article" @default.
• W2284151925 hasAuthorship W2284151925A5007346525 @default.
• W2284151925 hasAuthorship W2284151925A5017219333 @default.
• W2284151925 hasAuthorship W2284151925A5045470462 @default.
• W2284151925 hasAuthorship W2284151925A5071516359 @default.
• W2284151925 hasAuthorship W2284151925A5082207870 @default.
• W2284151925 hasBestOaLocation W22841519251 @default.

• next