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- W2284170829 abstract "Such is the state of schizophrenia genetics. After many years of searching, we now have 108 loci associated with schizophrenia at stringent, genome-wide levels of significance. 1 Schizophrenia Working Group of the Psychiatric Genomics ConsortiumBiological insights from 108 schizophrenia-associated genetic loci. Nature. 2014; 511: 421-427 Crossref PubMed Scopus (5094) Google Scholar Additional genes have been implicated by studies of copy number variants, 2 Malhotra D Sebat J CNVs: harbingers of a rare variant revolution in psychiatric genetics. Cell. 2012; 148: 1223-1241 Summary Full Text Full Text PDF PubMed Scopus (583) Google Scholar de-novo mutations, 3 Gulsuner S Walsh T Watts AC et al. Spatial and temporal mapping of de novo mutations in schizophrenia to a fetal prefrontal cortical network. Cell. 2013; 154: 518-529 Summary Full Text Full Text PDF PubMed Scopus (388) Google Scholar and rare coding variants. 4 Purcell SM Moran JL Fromer M et al. A polygenic burden of rare disruptive mutations in schizophrenia. Nature. 2014; 506: 185-190 Crossref PubMed Scopus (1004) Google Scholar Compared with the state of schizophrenia genetics 10 years ago, we have indeed been given much! Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approachOur results support genetic overlap between schizophrenia pathogenesis and antipsychotic mechanism of action. This finding is consistent with treatment efficacy being polygenic and suggests that single-target therapeutics might be insufficient. We provide evidence of a role for rare functional variants in antipsychotic treatment response, pointing to a subset of patients where their genetic information could inform treatment. Finally, we present a novel framework for identifying treatments from genetic data and improving our understanding of therapeutic mechanism. Full-Text PDF" @default.
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- W2284170829 date "2016-04-01" @default.
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- W2284170829 title "Genetic association studies in psychiatry: time for pay-off" @default.
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- W2284170829 doi "https://doi.org/10.1016/s2215-0366(16)00016-x" @default.
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